Spiromustine
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Names
[ CAS No. ]:
56605-16-4
[ Name ]:
Spiromustine
[Synonym ]:
Spirohydantoin mustard
3-{2-[bis-(2-chloro-ethyl)-amino]-ethyl}-1,3-diaza-spiro[4.5]decane-2,4-dione
3-<2-<bis(2'-chloroethyl)amino>-ethyl>-5,5-pentamethylenehydantoin
Spiromustine
3-<2-<Bis-(2'-chlorethyl)amino>-ethyl>-5,5-pentamethylen-hydantoin
NCI172112
Chemical & Physical Properties
[ Density]:
1.29g/cm3
[ Melting Point ]:
125.5°C
[ Molecular Formula ]:
C14H23Cl2N3O2
[ Molecular Weight ]:
336.25700
[ Exact Mass ]:
335.11700
[ PSA ]:
52.65000
[ LogP ]:
2.28740
[ Index of Refraction ]:
1.56
[ Storage condition ]:
2-8℃
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HM2508000
- CHEMICAL NAME :
- 1,3-Diazaspiro(4.5)decane-2,4-dione, 3-(2-(bis(2-chloroethyl)amino)ethyl)-
- CAS REGISTRY NUMBER :
- 56605-16-4
- BEILSTEIN REFERENCE NO. :
- 0757144
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C14-H23-Cl2-N3-O2
- MOLECULAR WEIGHT :
- 336.30
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 243 ug/kg/3W-I
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9100 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - chromodacryorrhea Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 33244 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 48280 ug/kg
- TOXIC EFFECTS :
- Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 3750 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Nutritional and Gross Metabolic - body temperature decrease
MUTATION DATA
- TYPE OF TEST :
- Body fluid assay
- TEST SYSTEM :
- Rodent - mouse Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 60 mg/kg
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 32,523,1983