Tanshinone I

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
498.0±24.0 °C at 760 mmHg

[ Melting Point ]:
233-234ºC

[ Molecular Formula ]:
C₁₈H₁₂O₃

[ Molecular Weight ]:
276.286

[ Flash Point ]:
245.9±15.6 °C

[ Exact Mass ]:
276.078644

[ PSA ]:
47.28000

[ LogP ]:
4.44

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.676

[ Storage condition ]:
2-8°C

Click to get detail MSDS

[ Hazard Statements ]:
H413

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Click to get detail synthetic route

Precursor

DownStream

Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").

J. Nat. Prod. 76(1) , 36-44, (2013)

The roots of Salvia miltiorrhiza ("Danshen") are used in traditional Chinese medicine for the treatment of numerous ailments including cardiovascular disease, hypertension, and ischemic stroke. Extrac...

Tanshinone IIA inhibits viral oncogene expression leading to apoptosis and inhibition of cervical cancer.

Cancer Lett. 356(2 Pt B) , 536-46, (2015)

Human papilloma virus (HPV) is the well-established etiological factor of cervical cancer. E6 and E7 oncoproteins expressed by HPV are known to inactivate tumor suppressor proteins p53 and pRb, respec...

Cloning, molecular characterization and functional analysis of 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase (HDR) gene for diterpenoid tanshinone biosynthesis in Salvia miltiorrhiza Bge. f. alba.

Plant Physiol. Biochem. 70 , 21-32, (2013)

The enzyme 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase (HDR) is a terminal-acting enzyme in the plastid MEP pathway, which produce isoprenoid precursors. The full-length cDNA of HDR, desi...

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