Eperisone hydrochloride

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Names

[ CAS No. ]:
56839-43-1

[ Name ]:
Eperisone hydrochloride

[Synonym ]:
MFCD00941459
1-(4-ethylphenyl)-2-methyl-3-piperidin-1-ylpropan-1-one,hydrochloride

Chemical & Physical Properties

[ Density]:
0.994g/cm3

[ Boiling Point ]:
386.8ºC at 760mmHg

[ Melting Point ]:
168-174ºC

[ Molecular Formula ]:
C17H26ClNO

[ Molecular Weight ]:
295.84700

[ Flash Point ]:
137.4ºC

[ Exact Mass ]:
295.17000

[ PSA ]:
20.31000

[ LogP ]:
4.29360

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UH1755000
CHEMICAL NAME :
Propiophenone, 4'-ethyl-2-methyl-3-piperidino-, hydrochloride
CAS REGISTRY NUMBER :
56839-43-1
LAST UPDATED :
199703
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C17-H25-N-O.Cl-H
MOLECULAR WEIGHT :
295.89
WISWESSER LINE NOTATION :
T6NTJ A1Y1&VR D2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1002 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 19,1743,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
490 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 21,939,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
51 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 21,939,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 21,939,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
324 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 107,705,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
256 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 21,939,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
43 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 21,939,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 21,939,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,204,1990 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
18200 mg/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 21,939,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
22313 mg/kg/1Y-I
TOXIC EFFECTS :
Blood - normocytic anemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Related to Chronic Data - death
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,7156,1982

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,3-Dioxolane
  • 4-Ethylpropiophenone
  • Piperidine hydrochloride

DownStream

  • Eperisone

Related Compounds

  • eperisone hydrochloride
  • Eperisone hydrochloride
  • Eperisone-d10 hydrochloride
  • carnitine hydrochloride
  • Losoxantrone hydrochloride [USAN]
  • Triprolidine hydrochloride
  • 4-(1-methyl-1H-pyrazol-4-yl)pyrrolidin-3-ol
  • rac-(3R,4S)-4-(thiophen-3-yl)oxolan-3-ol
  • 4-(1-methyl-1H-1,2,4-triazol-3-yl)pyrrolidin-3-ol
  • 4-[(1,3-Thiazol-4-yl)methyl]pyrrolidin-3-ol
  • rac-(1R,2S)-1-methyl-2-(pent-3-yn-1-yl)cyclohexan-1-ol
  • rac-(1R,2R)-2-(dimethyl-1,3-thiazol-5-yl)cyclopentan-1-ol
  • 1-cyclopentyl-5-(3-methylbutyl)-1H-1,2,3-triazole-4-carbaldehyde
  • 1-(3-methylbutan-2-yl)-5-(3-methylbutyl)-1H-1,2,3-triazole-4-carbaldehyde
  • 1-[2-(2-hydroxyethoxy)ethyl]-5-(3-methylbutyl)-1H-1,2,3-triazole-4-carbaldehyde
  • 1-(cyclopropylmethyl)-5-(3-methylbutyl)-1H-1,2,3-triazole-4-carbaldehyde
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