Chlorotrianisene

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Names

[ CAS No. ]:
569-57-3

[ Name ]:
Chlorotrianisene

[Synonym ]:
1-chloro-1,2,2-tris(p-methoxyphenyl)ethene
TACE
1,1',1''-(1-chloro-1-ethenyl-2-ylidene)tris[4-methoxy-benzene]
Chlortrianisestrol
Merbentul
Chlorestrolo
Chlorotrianisene
Tris-(4-methoxy-phenyl)-vinylchlorid
chloro-tris-(4-methoxy-phenyl)-ethene
Chlorotrianizen
Chlor-tris-(4-methoxy-phenyl)-aethen
Chlortrianisen
Chloortrianisestrol
1-[1-chloro-2,2-bis(4-methoxyphenyl)ethenyl]-4-methoxybenzene
Chlorotrianisine
Chlortrianizen
2-Chlor-1,1,2-tris-(4-methoxy-phenyl)-aethylen

Chemical & Physical Properties

[ Density]:
1.168g/cm3

[ Boiling Point ]:
514.2ºC at 760mmHg

[ Melting Point ]:
114-116ºC

[ Molecular Formula ]:
C23H21ClO3

[ Molecular Weight ]:
380.86400

[ Flash Point ]:
164.1ºC

[ Exact Mass ]:
380.11800

[ PSA ]:
27.69000

[ LogP ]:
5.86780

[ Index of Refraction ]:
1.591

[ Storage condition ]:
-70°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KV0600000
CHEMICAL NAME :
Ethylene, chlorotris(p-methoxyphenyl)-
CAS REGISTRY NUMBER :
569-57-3
BEILSTEIN REFERENCE NO. :
1891845
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C23-H21-Cl-O3
MOLECULAR WEIGHT :
380.89
WISWESSER LINE NOTATION :
1OR DYGUYR DO1&R DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
37 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Behavioral - changes in motor activity (specific assay)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 11,489,1967
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg/89W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - tumors Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
AMPLAO AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60. For publisher information, see APLMAS. Volume(issue)/page/year: 50,750,1950 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
48 mg/kg
SEX/DURATION :
female 14 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
OBGNAS Obstetrics and Gynecology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1953- Volume(issue)/page/year: 8,399,1956 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 21,139,1979 TOXICOLOGY REVIEW ACRSAJ Advances in Cancer Research. (Academic Press, Inc., 465 S. Lincoln Dr., Troy, MO 63379) V.1- 1953- Volume(issue)/page/year: 1,173,1953 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84523 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1134 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84523 No. of Facilities: 18 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 229 (estimated) No. of Female Employees: 114 (estimated)

Safety Information

[ WGK Germany ]:
3

[ RTECS ]:
KV0600000

Synthetic Route

Precursor & DownStream

Precursor

  • Anisole
  • 1,2,2-tris(4-methoxyphenyl)ethanone
  • Benzeneacetaldehyde,4-methoxy-a-oxo-
  • 1-bromo-1,2,2-tris(p-methoxyphenyl)ethene
  • Benzene,1,1'-(2,2,2-trichloroethylidene)bis[4-methoxy-
  • DIMETHYL(4-METHOXYBENZYL)PHOSPHONATE
  • 4-Methoxybenzylchloride
  • DMBP
  • Dimethyl 1-chloro-1-(4-methoxyphenyl)methanephosphonate
  • Ethyl (4-methoxyphenyl)acetate

DownStream

  • 9-chloro-3,6-dimethoxy-10-(p-methoxyphenyl)phenanthrene
  • DMBP
  • Benzene,1,1',1''-(1-ethenyl-2-ylidene)tris[4-methoxy-

Related Compounds

  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-{[(Tert-butoxy)carbonyl]amino}spiro[2.5]octane-1-carboxylic acid
  • 4-{4-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl}butan-2-amine
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 1-methyl-5-(oxiran-2-yl)-1H-1,2,3-triazole