cholesterol
Suppliers
Names
[ CAS No. ]:
57-88-5
[ Name ]:
cholesterol
[Synonym ]:
20-Dihydro-11-deoxycortisol
cholesterin
D5-Cholesten-3b-ol
20-Dihydro Cortexolone
3b-Hydroxy-5-cholestene
5:6-Cholesten-3b-ol
(3β)-Cholest-5-en-3-ol
δ5-Cholesten-3β-ol
cholest-5-en-3-ol, (3b)-
Cholest-5-en-3-ol (3β)-
Cholest-5-en-3b-ol
EINECS 200-353-2
5-Cholesten-3B-ol
5-Cholesten-3β-ol
Cholesterol
(3b)-cholest-5-en-3-ol
3β-Hydroxycholest-5-ene
5:6-Cholesten-3β-ol
(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methyl-2-heptanyl]-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
7α-Cholesterol
MFCD00003646
Cholest-5-en-3-ol, (3β)-
(-)-Cholesterol
Cholest-5-en-3β-ol
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
360 ºC
[ Melting Point ]:
148-150 °C
[ Molecular Formula ]:
C27H46O
[ Molecular Weight ]:
386.654
[ Flash Point ]:
250 ºC
[ Exact Mass ]:
386.354858
[ PSA ]:
20.23000
[ LogP ]:
9.85
[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C
[ Index of Refraction ]:
1.525
[ Water Solubility ]:
negligible
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- FZ8400000
- CHEMICAL NAME :
- Cholesterol
- CAS REGISTRY NUMBER :
- 57-88-5
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 22
- MOLECULAR FORMULA :
- C27-H46-O
- MOLECULAR WEIGHT :
- 386.73
- WISWESSER LINE NOTATION :
- L E5 B666 LUTJ A1 E1 FY1&3Y1&1 OQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2100 mg/kg/12W-C
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - recording from peripheral motor nerve Sense Organs and Special Senses (Ear) - changes in cochlear structure or function Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 12180 mg/kg/40W-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Endocrine - changes in spleen weight Blood - pigmented or nucleated red blood cells
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 800 mg/kg/43W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 15 gm/kg/47W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Implant
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 60 gm/kg/2W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 175 mg/kg
- SEX/DURATION :
- female 8-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 1900 mg/kg
- SEX/DURATION :
- female 1-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 6 gm/kg
- SEX/DURATION :
- female 1-31 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Newborn - stillbirth
MUTATION DATA
- TYPE OF TEST :
- DNA adduct
- TEST SYSTEM :
- Rodent - mouse Cells - not otherwise specified
- DOSE/DURATION :
- 1 umol/L
- REFERENCE :
- CJBBDU Canadian Journal of Biochemistry and Cell Biology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.61- 1983- Volume(issue)/page/year: 62,94,1984 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 10,99,1976 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,95,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,161,1987 TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80865 No. of Facilities: 1321 (estimated) No. of Industries: 8 No. of Occupations: 10 No. of Employees: 13980 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80865 No. of Facilities: 4091 (estimated) No. of Industries: 5 No. of Occupations: 11 No. of Employees: 41411 (estimated) No. of Female Employees: 30220 (estimated)
Safety Information
[ Symbol ]:
GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H315-H319-H331-H336-H351-H361d-H372
[ Precautionary Statements ]:
P201-P261-P304 + P340 + P312-P305 + P351 + P338-P308 + P313-P403 + P233
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
R10
[ Safety Phrases ]:
S24/25-S22-S36/37
[ RIDADR ]:
UN 1170 3/PG 3
[ WGK Germany ]:
1
[ RTECS ]:
FZ8400000
[ Hazard Class ]:
3.0
[ HS Code ]:
2906131000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2906131000
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