isonixin

Names

[ Name ]:
isonixin

[Synonym ]:
Nixyn hermes
N-(2,6-Dimethylphenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide
Nixyn
1,2-Dihydro-2-oxo-N-(2,6-xylyl)-3-pyridinecarboxamide
Isonixine

Chemical & Physical Properties

[ Density]:
1.244g/cm3

[ Boiling Point ]:
520.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₄N₂O₂

[ Molecular Weight ]:
242.27300

[ Flash Point ]:
217.5ºC

[ Exact Mass ]:
242.10600

[ PSA ]:
61.96000

[ LogP ]:
2.31700

[ Index of Refraction ]:
1.628

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US4600000

CHEMICAL NAME :: 3-Pyridinecarboxamide, 1,2-dihydro-2-oxo-N-(2,6-xylyl)-

CAS REGISTRY NUMBER :: 57021-61-1

LAST UPDATED :: 199210

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C14-H14-N2-O2

MOLECULAR WEIGHT :: 242.30

WISWESSER LINE NOTATION :: T6MVJ CVMR B1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1457,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1457,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1457,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1457,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 281 gm/kg/26W-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - death

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1460,1977

Related Compounds

2-(Difluoromethyl)-3-iodo-6-methoxypyridine-5-acetonitrile
2-(Difluoromethyl)-3-methoxy-4-methylpyridine-6-carboxaldehyde
2-(Difluoromethyl)-3-fluoro-5-(trifluoromethyl)pyridine-6-acetic acid
2-(Difluoromethyl)-4-fluoro-5-iodopyridine-3-carboxamide
2-(Difluoromethyl)-4-fluoro-3-methoxypyridine-6-sulfonamide
2-(Difluoromethyl)-3-methoxy-4-nitropyridine-5-carboxylic acid
2-(Chloromethyl)-7-(trifluoromethyl)benzo[d]oxazole
2-(Difluoromethyl)-4-fluoro-5-methylpyridine-3-acetonitrile
2-(Difluoromethyl)-3-hydroxy-4-methylpyridine-5-acetic acid
2-(Difluoromethoxy)-3-(trifluoromethyl)naphthalene

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