BENZOHYDROQUINONE

Names

[ CAS No. ]:
571-60-8

[ Name ]:
BENZOHYDROQUINONE

[Synonym ]:
BENZOHYDROQUINONE
1,4-Naphthalenediol
EINECS 209-336-4
MFCD00003977
1,4-Dihydroxynaphthalene
Naphthalene-1,4-diol

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
391.0±15.0 °C at 760 mmHg

[ Melting Point ]:
191-192 °C (dec.)

[ Molecular Formula ]:
C₁₀H₈O₂

[ Molecular Weight ]:
160.169

[ Flash Point ]:
202.5±15.0 °C

[ Exact Mass ]:
160.052429

[ PSA ]:
40.46000

[ LogP ]:
1.88

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.726

[ Water Solubility ]:
slightly soluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ4730000

CHEMICAL NAME :: 1,4-Naphthalenediol

CAS REGISTRY NUMBER :: 571-60-8

BEILSTEIN REFERENCE NO. :: 1307689

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H8-O2

MOLECULAR WEIGHT :: 160.18

WISWESSER LINE NOTATION :: L66J BQ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 5 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 371,293,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3916 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 56 (estimated) No. of Female Employees: 35 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R25;R36/37/38;R43

[ Safety Phrases ]:
S26-S39-S45-S36/37/39-S28A-S24

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
QJ4730000

[ HS Code ]:
2907299090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2907299090

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

Articles

2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents.

Eur. J. Med. Chem. 44 , 1086-92, (2009)

A series of 2-chloro-3-arylsulfanyl-[1,4]naphthoquinones (2), 2,3-bis-arylsulfanyl-[1,4]naphthoquinones (3) and 12H-benzo[b]phenothiazine-6,11-diones and their analogs 6-8 were synthesized and evaluat...

A laccase-catalysed one-pot synthesis of aminonaphthoquinones and their anticancer activity

Bioorg. Med. Chem. 20(14) , 4472-81, (2012)

Nuclear monoamination of a 1,4-naphthohydroquinone with primary aromatic amines was catalysed by the commercial laccase, Novozym 51003, from Novozymes to afford aminonaphthoquinones. The synthesis was...

Dual effects of superoxide dismutase on the autoxidation of 1,4-naphthohydroquinone.

Free Radic. Biol. Med. 8(1) , 21-4, (1990)

The autoxidation of 1,4-naphthohydroquinone, in a phosphate, EDTA buffer at pH 7.4, exhibits an autocatalysis whose lag phase becomes more pronounced in the presence of either the Cu,Zn- or the Mn-con...