6-TRIFLUOROMETHYLCYCLOPHOSPHAMIDE

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Names

[ CAS No. ]:
57165-71-6

[ Name ]:
6-TRIFLUOROMETHYLCYCLOPHOSPHAMIDE

[Synonym ]:
6-Trifluoromethylcyclophosphamide

Chemical & Physical Properties

[ Density]:
1.44g/cm3

[ Boiling Point ]:
336.3ºC at 760 mmHg

[ Molecular Formula ]:
C8H14Cl2F3N2O2P

[ Molecular Weight ]:
329.08400

[ Flash Point ]:
157.2ºC

[ Exact Mass ]:
328.01200

[ PSA ]:
51.38000

[ LogP ]:
3.14370

[ Index of Refraction ]:
1.464

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP6159000
CHEMICAL NAME :
2H-1,3,2-Oxazaphosphorine, tetrahydro-2-(bis(2-chloroethyl)amino)-6-trifluoromet hyl-, 2-oxide
CAS REGISTRY NUMBER :
57165-71-6
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H14-Cl2-F3-N2-O2-P
MOLECULAR WEIGHT :
329.11
WISWESSER LINE NOTATION :
T6MPOTJ BO BN2G2G DXFFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
224 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,1106,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,1106,1975

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Bis(2-chloroethyl)aminophosphonic dichloride
  • 1-amino-3-hydroxy-4,4,4-trifluorobutane

DownStream

Related Compounds

  • 6-(17,19-Dimethylhenicosyl)tetrahydro-2H-pyran-2-dodecanoic acid methyl ester
  • 6-methoxyaromadendrin 3-O-acetate
  • 6,6,6-trifluoro-5-hydroxy-2,2-dimethyl-5-(trifluoromethyl)hexan-3-one
  • 6-methyl-1,3-thiazinane-2-thione
  • 6-chloro-3-[(dimethylamino)methyl]-3H-2-benzothiophen-1-one,hydrochloride
  • 6-(4-T-BUTYLPHENYL)-6-OXOHEXANOIC ACID
  • 6-(Trifluoromethoxy)-1-naphthaldehyde
  • 6-Amino-5-(difluoromethyl)-4-hydroxypicolinaldehyde
  • 2,3-Dibromo-4-(difluoromethyl)-5-methoxypyridine
  • 2,5-Dibromo-3-fluorobenzotrifluoride
  • 2-(2-Bromo-5-fluoropyridin-3-yl)acetic acid
  • 3-(Trifluoromethoxy)-2-naphthaldehyde
  • 2'-Bromo-6'-chloro-4'-(trifluoromethyl)acetophenone
  • 4-(Difluoromethyl)-3-formyl-6-hydroxypicolinonitrile
  • 7-((Trifluoromethyl)thio)benzo[d]oxazol-2-amine
  • 2-Bromo-5-cyano-4-(difluoromethyl)pyridine-3-sulfonamide
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