4-Methyl-L-leucine

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Names

[ CAS No. ]:
57224-50-7

[ Name ]:
4-Methyl-L-leucine

[Synonym ]:
Glycine, N-(2,2-dimethylpropyl)-
4-Methyl-L-leucine
MFCD00066079
2(S)-amino-4,4-dimethylpentanoic acid
Neopentylglycine
L-Leucine, 4-methyl-
3-tert-Butyl-L-alanine
N-(2,2-Dimethylpropyl)glycine
L-neopentylglycine
4-METHYL-LEUCINE
(S)-2-amino-4,4-dimethyl-pentanoic acid

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
226.1±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C7H15NO2

[ Molecular Weight ]:
145.199

[ Flash Point ]:
90.6±22.6 °C

[ Exact Mass ]:
145.110275

[ PSA ]:
63.32000

[ LogP ]:
0.97

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.449

[ Storage condition ]:
Store at RT.

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (S)-Methyl 2-amino-4,4-dimethylpentanoate
  • 4,4-Dimethyl-2-oxo-pentanoic acid

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

The specificity and kinetic mechanism of branched-chain amino acid aminotransferase from Escherichia coli studied with a new improved coupled assay procedure and the enzyme's potential for biocatalysis.

FEBS J. 281(1) , 391-400, (2014)

Branched-chain amino acid aminotransferase (BCAT) plays a key role in the biosynthesis of hydrophobic amino acids (such as leucine, isoleucine and valine), and its substrate spectrum has not been full...

Synthesis of gamma-methyl-L-leucine (neopentylglycine, Neo) and derivatives suitable for peptide synthesis.

Int. J. Pept. Protein Res. 18 , 249, (1981)

The modified Strecker synthesis of Patel & Worsley was combined with an enzymatic deamidation in the final step, to produce the title compound. The amino acid is a member of the family of the "fat" am...


More Articles

Related Compounds

  • 4-Methyl-L-leucine
  • N-Acetyl-4-methyl-L-leucine
  • N-Acetyl-4-methyl-L-leucine
  • N-[(1,1-Dimethylethoxy)carbonyl]-4-methyl-L-leucine
  • N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-methyl-L-leucine
  • 4-Methyl-L-tryptophan
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-{2-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]-1H-pyrrol-1-yl}-N-(2-methoxyethyl)acetamide
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide