Pamidronate disodium
Suppliers
Names
[ CAS No. ]:
57248-88-1
[ Name ]:
Pamidronate disodium
[Synonym ]:
Disodium (3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogen (phosphonate)]
Pamidronate disodium salt
Pamidronate disodium
Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, sodium salt (1:2)
Dinatrium-(3-amino-1-hydroxypropan-1,1-diyl)bis[hydrogen-(phosphonat)]
APD
Disodium (3-amino-1-hydroxy-1-phosphonopropyl)phosphonate
MFCD01938386
EINECS 260-647-1
(3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogène (phosphonate)] de disodium
Pamidronate (Disodium)
Chemical & Physical Properties
[ Melting Point ]:
300 °C
[ Molecular Formula ]:
C3H11NNa2O7P2
[ Molecular Weight ]:
281.05
[ PSA ]:
186.59000
[ Appearance of Characters ]:
solid | white
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
H2O: 28 mg/mL
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SZ6525000
- CHEMICAL NAME :
- Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, disodium salt
- CAS REGISTRY NUMBER :
- 57248-88-1
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C3-H9-N-O7-P2.2Na
- MOLECULAR WEIGHT :
- 279.05
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 750 ug/kg/5D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Eye) - diplopia Sense Organs and Special Senses (Eye) - effect, not otherwise specified
- REFERENCE :
- ANZJB8 Australian and New Zealand Journal of Medicine. (Modern Medicine of Australia Pty., Ltd., 100 Pacific Highway, North Sydney, 2060, Australia) V.1- 1971- Volume(issue)/page/year: 24,320,1994
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 600 ug/kg/6H-C
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - changes in calcium
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,622,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 900 ug/kg
- TOXIC EFFECTS :
- Musculoskeletal - joints
- REFERENCE :
- APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992- Volume(issue)/page/year: 31,499,1997 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1740 mg/kg
- SEX/DURATION :
- female 15-22 day(s) after conception lactating female 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,654,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 60 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,654,1992
Safety Information
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
R22:Harmful if swallowed. R48:Danger of serious damage to health by prolonged exposure. R41:Risk of serious damage to eyes. R37/38:Irritating to respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
[ Safety Phrases ]:
S22:Do not breathe dust . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek m
[ WGK Germany ]:
3
[ RTECS ]:
SZ6525000
[ HS Code ]:
2931900090
Customs
[ HS Code ]: 2931900090
[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%