1-Acetyl-1H-indole-2,3-dione

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Names

[ CAS No. ]:
574-17-4

[ Name ]:
1-Acetyl-1H-indole-2,3-dione

[Synonym ]:
1-Acetyl-1H-indole-2,3-dione
1-acetylindole-2,3-dione
MFCD00158542
EINECS 209-368-9

Chemical & Physical Properties

[ Density]:
1.413 g/cm3

[ Boiling Point ]:
345.4ºC at 760 mmHg

[ Melting Point ]:
141-143°C

[ Molecular Formula ]:
C10H7NO3

[ Molecular Weight ]:
189.16700

[ Flash Point ]:
165.8ºC

[ Exact Mass ]:
189.04300

[ PSA ]:
54.45000

[ LogP ]:
0.82740

[ Index of Refraction ]:
1.617

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NL7873800
CHEMICAL NAME :
Indole-2,3-dione, 1-acetyl-
CAS REGISTRY NUMBER :
574-17-4
BEILSTEIN REFERENCE NO. :
0144609
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H7-N-O3
MOLECULAR WEIGHT :
189.18
WISWESSER LINE NOTATION :
T56 BNVVJ BV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,22,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
809 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 15,858,1981

Safety Information

[ Safety Phrases ]:
S22-S24/25

[ RTECS ]:
NL7873800

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • isatin
  • Acetyl chloride
  • Ethanoic anhydride
  • N-(2-acetylamino)phenylglyoxylyl-N'-acetylhydrazine
  • N-trifluoroacetylisatin
  • 1,1'-diacetyl-3,3'-dihydroxy-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione

DownStream

  • Hydrazinecarbothioamide,2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-
  • Z-3-thiosemicarbazone of 1-acetylisatin
  • o-(acetylamino)phenylglyoxylothiosemicarbazide
  • 1H-indole-2,3-dione, 3-oxime
  • 6H-pyrido<3',4':5,6>pyrazino<2,3-b>indole
  • Oxindole
  • ethyl 2-(2-acetamidophenyl)-2-oxo-acetate
  • N-acetylisatic acid
  • isatin
  • N-Acetylanthranilic acid

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 1-Acetyl-1H-indole-2,3-dione 3-((2-(hydroxy(oxido)amino)phenyl)hydrazone)
  • 1-acetyl-3-hydroxyiminoindol-2-one
  • 1-acetyl-5-methylindole-2,3-dione
  • AKOS BBS-00001025
  • 6-fluoro-1-acetyl indole-2,3-dione
  • 5-chloro-1H-indole-2,3-dione 3-oxime
  • 4-(4-Methoxybenzenesulfonyl)-3-[(morpholin-4-yl)methyl]-1,4-thiazepane
  • 1-(4-Phenylpiperazin-1-yl)-2-(4-(thiophen-2-yl)piperidin-1-yl)ethanone
  • 1-(4-Methoxyphenyl)-2-(4-(thiophen-2-yl)piperidin-1-yl)ethanone
  • 3-[2-(Trifluoromethyl)phenyl]piperidin-2-one
  • N,5-dicyclopropyl-N-(imidazo[1,2-a]pyridin-3-ylmethyl)isoxazole-3-carboxamide
  • 2,4-dichloro-N-cyclopropyl-N-(imidazo[1,2-a]pyridin-3-ylmethyl)-5-methylbenzenesulfonamide
  • 6-(3,5-Dichlorophenyl)piperidin-2-one
  • 2-{[(benzyloxy)carbonyl]amino}-3-(4-methyl-1H-pyrazol-1-yl)propanoic acid
  • N-ethyl-N-(imidazo[1,2-a]pyridin-3-ylmethyl)-5-methylthiophene-2-sulfonamide
  • N-(2-(2-(3,5-dimethyl-1H-pyrazol-1-yl)thiazol-4-yl)ethyl)-2-phenylacetamide
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