(±)-Nornicotine

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Names

[ Name ]:
(±)-Nornicotine

[Synonym ]:
3-pyrrolidin-2-yl-pyridine
EINECS 200-659-6
NORNICOTINE,DL
2-[3-PYRIDYL]PYRROLIDINE
(+/-)-nor-nicotine
(2S)-2-(3-Pyridinyl)pyrrolidinium
2-(3-pyridyl)pyrollidine
MFCD00016913
2-[3-PYRIDYL]PYRROLIDONE
DL-NORNICOTINE
2-(3-Pyridinyl)pyrrolidine
(R,S)-NORNICOTINE
Pyrrolidinium, 2-(3-pyridinyl)-, (2S)-

Chemical & Physical Properties

[ Density]:
1,074 g/cm3

[ Boiling Point ]:
107-108°C 2mm

[ Molecular Formula ]:
C₉H₁₂N₂

[ Molecular Weight ]:
148.20500

[ Flash Point ]:
101°C

[ Exact Mass ]:
148.10000

[ PSA ]:
24.92000

[ LogP ]:
1.83490

[ Index of Refraction ]:
1.54

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: 50 mg/mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QS6350000

CHEMICAL NAME :: Nicotine, 1'-demethyl-, (+-)-

CAS REGISTRY NUMBER :: 5746-86-1

LAST UPDATED :: 199206

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H12-N2

MOLECULAR WEIGHT :: 148.23

WISWESSER LINE NOTATION :: T6NJ C- BT5MTJ -+-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18750 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S36/37

[ RIDADR ]:
2810

[ WGK Germany ]:
3

[ RTECS ]:
QS6350000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

Myosmine
2-(3-Pyridinyl)-2-pyrroline
3-[1-(4-toulenesulfonyl)pyrrolidin-2-yl]pyridine
3-Bromo-5-(2-pyrrolidinyl)pyridine
3-Vinyl-2-pyrrolidinone
N-tosyl-2-(3-pyridyl)-4-methylenepyrrolidine
5-Bromonicotinic acid

DownStream

(S)-Nornicotine
(R)-3-(pyrrolidin-2-yl)pyridine
Nicotinic acid
(+/-)-nicotine-methyl-d3
N-Formylnornicotine
(±)-nicotine
L-Nicotine
(+)-Nicotine
(R,S)-N-Ethylnornicotine

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

6'-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the alpha4beta2 nicotinic receptor pharmacophore model.

Bioorg. Med. Chem. Lett. 15 , 877-81, (2005)

6'-Methylpyrido[3,4-b]norhomotropane [synthesis as the racemate reported here] is more potent at the alpha4beta2 nicotinic receptor than any previous bridged nicotinoid. The two nitrogens and 6'-methy...

3-(2-Aminoethyl)pyridine analogs as alpha4beta2 nicotinic cholinergic receptor ligands.

Bioorg. Med. Chem. Lett. 15 , 4308-12, (2005)

An examination of several 3-(2-aminoethyl)pyridine analogs suggests that they likely orient at alpha4beta2 nicotinic cholinergic receptors in a different fashion than their correspondingly substituted...

Abuse potential of non-nicotine tobacco smoke components: acetaldehyde, nornicotine, cotinine, and anabasine.

Nicotine Tob. Res. 15(3) , 622-32, (2013)

This review identified published animal studies evaluating the possible abuse potential of acetaldehyde, nornicotine, cotinine, and anabasine based on five commonly used paradigms. These include their...

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