[Nle11]-Substance P

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Names

[ CAS No. ]:
57462-42-7

[ Name ]:
[Nle11]-Substance P

[Synonym ]:
L-Norleucinamide, N-(diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-
substance P,NleNH2(11)
N-(diaminomethylidene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-norleucinamide
Substance P,[Nle11]
[Nle11 ]-substance P
N-(Diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-norleucinamide
[Nle11]-Substance P

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C64H100N18O13

[ Molecular Weight ]:
1329.592

[ Exact Mass ]:
1328.771729

[ PSA ]:
516.63000

[ LogP ]:
-0.18

[ Index of Refraction ]:
1.654

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Boc-Gly-OH
  • Boc-Leu-OH.H2O
  • Boc-L-phenylalanine
  • N-Boc-L-Norleucine

DownStream

Articles

In vitro activities of some synthetic substance P analogs.

Arch. Int. Pharmacodyn. Ther. 240 , 193, (1979)

Substance P (SP) and several analogs and fragments have been synthesized and evaluated on non-stimulated and stimulated guinea-pig ileum. In the former test system the potency order was as follows: SP...

Synthesis and biological activities of photoaffinity labeling analogues of substance P.

J. Med. Chem. 25 , 470, (1982)

Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2, SP) is an undecapeptide with important properties as a neurotransmitter and with other functions. No specific antagonists and no long-actin...

Some observations indicating a low brain uptake of [3H]Nle11-Substance P.

Pharmazie 38(2) , 108-10, (1983)

The studies concerning the problem of whether an exogenous neuropeptide is able to enter the brain tissue were extended to the undecapeptide Substance P (SP). The amount of radioactivity 15 s after in...


More Articles

Related Compounds

  • [Tyr8,Nle11] Substance P
  • [D-Pro4,D-Trp7,9,Nle11]-Substance P (4-11)
  • (D-Lys(nicotinoyl)1,β-(3-pyridyl)-Ala3,3,4-dichloro-D-Phe5,Asn6,D-Trp7·9,Nle11)-Substance P trifluoroacetate salt
  • Biotin-Substance P
  • (Tyr8)-Substance P
  • [Sar9] Substance P
  • 3-Thiophenepropanoic acid, I(2)-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methoxy-
  • 3-Hydroxy-2-(1-methylethyl)-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde
  • Ethyl 6-methyl-3-oxo-2-(2-oxopentyl)heptanoate
  • (1-Methyl-9H-fluoren-2-yl)phenylmethanone
  • 2-[(5-Methyl-5H-pyrrolo[2,3-b]pyrazin-7-yl)methylene]hydrazinecarbothioamide
  • 7-Cyclopropyl-2-methyl-[1,2,4]triazolo[1,5-a]pyridine-5-carboxylic acid
  • 5-chloro-2-(3-chloropropyl)-1-methyl-1H-imidazole
  • [3-(4-Chloro-3-methylphenyl)-1,1-difluoropropan-2-yl]hydrazine
  • methyl 3-(2-amino-1H-imidazol-1-yl)-2-hydroxypropanoate
  • 3-Pyridinecarboxylic acid, 6-methyl-2-(2,4,5-trichlorophenyl)-, methyl ester
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