L-γ-Glutamyl-S-nitroso-L-cysteinylglycine

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Names

[ CAS No. ]:
57564-91-7

[ Name ]:
L-γ-Glutamyl-S-nitroso-L-cysteinylglycine

[Synonym ]:
L-γ-Glutamyl-S-nitroso-L-cysteinylglycine
glycine, N-(N-L-γ-glutamyl-S-nitroso-L-cysteinyl)-
Glycine, L-γ-glutamyl-S-nitroso-L-cysteinyl-
S-Nitroso-L-glutathione
S-NITROSOGLUTATHIONE
MFCD00214341
EINECS 248-170-7

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Melting Point ]:
>170ºC (dec.)

[ Molecular Formula ]:
C10H16N4O7S

[ Molecular Weight ]:
336.322

[ Exact Mass ]:
336.073975

[ PSA ]:
213.55000

[ LogP ]:
-0.26

[ Index of Refraction ]:
1.656

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MC0558000
CHEMICAL NAME :
Glycine, N-(N-L-gamma-glutamyl-2-nitroso-L-cysteinyl)-
CAS REGISTRY NUMBER :
57564-91-7
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H16-N4-O7-S
MOLECULAR WEIGHT :
336.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
5 umol/plate
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 35,3847,1986

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MC0558000

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Glutathione
  • 4,7-dimethyl-1,2,5-oxadiazolo[3,4-d]pyridazine 1,5,6-trioxide
  • t-butyl nitrite
  • Isopropyl nitrite
  • Ethanol solution
  • 2-chloroethyl nitrite
  • 2-ethoxyethyl nitrite
  • 2-bromoethyl nitrite
  • Isopentyl nitrite

DownStream

  • 4-Nitrosomorpholine
  • L(-)-Glutathione
  • Glutathione
  • N-Acetyl-3-(nitrososulfanyl)valine
  • Benzenesulfohydroxamic Acid
  • (2S)-2-amino-5-[[(2R)-3-(benzenesulfonylsulfanyl)-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
  • 2,2'-(Nitrosoimino)diethanol
  • L-CYSTEINE-GLUTATHIONE DISULFIDE

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Down regulation of NO signaling in Trypanosoma cruzi upon parasite-extracellular matrix interaction: changes in protein modification by nitrosylation and nitration.

PLoS Negl. Trop. Dis. 9 , e0003683, (2015)

Adhesion of the Trypanosoma cruzi trypomastigotes, the causative agent of Chagas' disease in humans, to components of the extracellular matrix (ECM) is an important step in host cell invasion. The sig...

Lipopolysaccharides Promote S-Nitrosylation and Proteasomal Degradation of Liver Kinase B1 (LKB1) in Macrophages in Vivo.

J. Biol. Chem. 290 , 19011-7, (2015)

LKB1 (liver kinase B1) plays important roles in tumor suppression, energy metabolism, and, recently, in innate immune responses. However, how LKB1 is regulated under physiological or pathological cond...

S-nitrosylation triggers ABI5 degradation to promote seed germination and seedling growth.

Nat. Commun. 6 , 8669, (2015)

Plant survival depends on seed germination and progression through post-germinative developmental checkpoints. These processes are controlled by the stress phytohormone abscisic acid (ABA). ABA regula...


More Articles

Related Compounds

  • L-γ-glutamyl-S-dimethylphosphinothioyl-L-cysteinylglycine
  • L-γ-Glutamyl-S-[2-(2-amino-6-oxo-3,6-dihydro-7H-purin-7-yl)(2H4)ethyl]-L-cysteinylglycine
  • S-glyceroylglutathione
  • S-NONYLGLUTATHIONE
  • N-(t-butoxycarbonyl)-L-γ-glutamyl-S-dimethylphosphinothioyl-L-cysteinylglycine di-t-butyl ester
  • S-(Hexamethylcarbamoyl)glutathione
  • tert-butyl N-[1-(5-bromopyrimidin-2-yl)-2-oxoethyl]-N-methylcarbamate
  • tert-butyl N-{2-[(azetidin-3-yl)methyl]-5-chlorophenyl}carbamate
  • 2-(1-{1-[(Tert-butoxy)carbonyl]piperidin-2-yl}cyclobutyl)acetic acid
  • 1-(2-{[(Tert-butoxy)carbonyl]amino}-5-methoxyphenyl)-3-hydroxycyclobutane-1-carboxylic acid
  • tert-butyl N-[3-amino-2-(2-chloro-5-fluorophenyl)-2-methylpropyl]carbamate
  • tert-butyl N-[2-(3-hydroxy-4-methylphenyl)-1-oxopropan-2-yl]carbamate
  • tert-butyl N-[1-(3,5-dimethoxy-4-methylphenyl)-2-oxoethyl]-N-methylcarbamate
  • tert-butyl N-[3-amino-2-(2-chloro-4,5-difluorophenyl)-2-methylpropyl]carbamate
  • tert-butyl N-[2-amino-1-(3-methyl-2-nitrophenyl)ethyl]carbamate
  • tert-butyl N-[2-(2-amino-2-methylpropyl)-5-methoxyphenyl]carbamate
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