1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin

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Names

[ CAS No. ]:
57653-85-7

[ Name ]:
1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin

[Synonym ]:
1,2,3,6,7,8-hexachlorodibenzo-p-dioxin

Chemical & Physical Properties

[ Density]:
1.777 g/cm3

[ Boiling Point ]:
478ºC at 760 mmHg

[ Melting Point ]:
285-286ºC

[ Molecular Formula ]:
C12H2Cl6O2

[ Molecular Weight ]:
390.86100

[ Flash Point ]:
182.9ºC

[ Exact Mass ]:
387.81900

[ PSA ]:
18.46000

[ LogP ]:
7.50500

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HP3280100
CHEMICAL NAME :
Dibenzo-p-dioxin, 1,2,3,6,7,8-hexachloro-
CAS REGISTRY NUMBER :
57653-85-7
BEILSTEIN REFERENCE NO. :
1627652
LAST UPDATED :
199806
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C12-H2-Cl6-O2
MOLECULAR WEIGHT :
390.84

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1250 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
70 ug/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
140 ug/kg/14D-C
TOXIC EFFECTS :
Immunological Including Allergic - decrease in humoral immune response

MUTATION DATA

TYPE OF TEST :
Morphological transformation
TEST SYSTEM :
Rodent - mouse Fibroblast
DOSE/DURATION :
400 pmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,1485,1987 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,41,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,41,1977 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 69,33,1997

Safety Information

[ RIDADR ]:
UN 2811

[ Packaging Group ]:
I

[ Hazard Class ]:
6.1(a)

Synthetic Route

Click to get detail synthetic route

Related Compounds

  • 1,2,3,6,7,8-hexachlorodibenzo-p-dioxin
  • 1,2,3,6,7,8-HEXACHLORODIBENZO-P-DIOXIN
  • 1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin
  • 1,2,3,4,7,8-Hexachlorodibenzo-P-Dioxin (13C12, 99%) 50 Ug/Ml In Nonane
  • 1,2,3,6,8,9-hexachlorodibenzo-p-dioxin
  • 1,2,3,4,6,8-hexachlorodibenzo-p-dioxin
  • (2R,3R,4R,5R)-3,4-Dihydroxy-2,5-bis(hydroxymethyl)-1-pyrrolidinepropanoic acid
  • 3,3-Difluoro-2-hydroxybutanoic acid
  • Ethyl 2-(5-fluorofuran-2-yl)-1,3-thiazole-5-carboxylate
  • methyl 5-(1-cyanoethyl)-1-methyl-1H-pyrazole-3-carboxylate
  • 1-(Benzylamino)-5,6-dimethylhept-5-en-2-one
  • 4-Fluoro-2,3-dihydro-1lambda6-benzothiophene-1,1,3-trione
  • 1-(5-Chloropyridin-2-yl)-2-(pyrrolidin-2-yl)ethan-1-one
  • 1-{3-[2-(Difluoromethyl)pyridin-4-yl]phenyl}ethan-1-one
  • 1-cyclopentyl-1H-pyrazole-5-sulfonamide
  • 2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-1,3-benzoxazole-6-carboxylic acid
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