1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin
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Names
[ CAS No. ]:
57653-85-7
[ Name ]:
1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin
[Synonym ]:
1,2,3,6,7,8-hexachlorodibenzo-p-dioxin
Chemical & Physical Properties
[ Density]:
1.777 g/cm3
[ Boiling Point ]:
478ºC at 760 mmHg
[ Melting Point ]:
285-286ºC
[ Molecular Formula ]:
C12H2Cl6O2
[ Molecular Weight ]:
390.86100
[ Flash Point ]:
182.9ºC
[ Exact Mass ]:
387.81900
[ PSA ]:
18.46000
[ LogP ]:
7.50500
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HP3280100
- CHEMICAL NAME :
- Dibenzo-p-dioxin, 1,2,3,6,7,8-hexachloro-
- CAS REGISTRY NUMBER :
- 57653-85-7
- BEILSTEIN REFERENCE NO. :
- 1627652
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C12-H2-Cl6-O2
- MOLECULAR WEIGHT :
- 390.84
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1250 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 70 ug/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 140 ug/kg/14D-C
- TOXIC EFFECTS :
- Immunological Including Allergic - decrease in humoral immune response
MUTATION DATA
- TYPE OF TEST :
- Morphological transformation
- TEST SYSTEM :
- Rodent - mouse Fibroblast
- DOSE/DURATION :
- 400 pmol/L
- REFERENCE :
- CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,1485,1987 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,41,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,41,1977 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 69,33,1997
Safety Information
[ RIDADR ]:
UN 2811
[ Packaging Group ]:
I
[ Hazard Class ]:
6.1(a)