Acetamide,N-[(7S)-5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl]-

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Names

[ CAS No. ]:
57866-21-4

[ Name ]:
Acetamide,N-[(7S)-5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl]-

[Synonym ]:
2,3-O-didemethylcolchicine
(S)-7-(Acetylamino)-6,7-dihydro-1,10-dimethoxy-2,3-dihydroxybenzo[a]heptalen-9(5H)-one
2,3-Didemethylcolchicin
2,3-Dimethylcolchicine
2,3-didemethylcolchicine

Chemical & Physical Properties

[ Density]:
1.38g/cm3

[ Boiling Point ]:
810.3ºC at 760mmHg

[ Molecular Formula ]:
C20H21NO6

[ Molecular Weight ]:
371.38400

[ Flash Point ]:
443.9ºC

[ Exact Mass ]:
371.13700

[ PSA ]:
105.09000

[ LogP ]:
2.65650

[ Index of Refraction ]:
1.642

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC8585750
CHEMICAL NAME :
Acetamide, N-(5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethoxy-9- oxobenzo(a)heptalen-7 -yl)-, (S)-
CAS REGISTRY NUMBER :
57866-21-4
LAST UPDATED :
199512
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H21-N-O6
MOLECULAR WEIGHT :
371.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJCIB8 European Journal of Clinical Investigation. (Blackwell Scientific Pub. Inc., 52 Beacon St., Boston, MA 02108) V.1- 1970- Volume(issue)/page/year: 22,630,1992

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Desmethylcolchicine
  • Colchicine

DownStream

  • Cornigerine

Related Compounds

  • 1,3,3-Trimethyl-1-{1-[2-(methylsulfanyl)pyrimidin-4-yl]piperidin-4-yl}urea
  • 1-[1-(6-Methoxypyridin-2-yl)piperidin-4-yl]-1,3,3-trimethylurea
  • 1-{1-[5-Cyano-2-(methylsulfanyl)pyrimidin-4-yl]piperidin-4-yl}-1,3,3-trimethylurea
  • 1,3,3-Trimethyl-1-{1-[6-methyl-2-(methylsulfanyl)pyrimidin-4-yl]piperidin-4-yl}urea
  • 1,3,3-Trimethyl-1-{1-[(pyridin-3-yl)methyl]piperidin-4-yl}urea
  • 1,3,3-Trimethyl-1-{1-[(2-methyl-1,3-oxazol-4-yl)methyl]piperidin-4-yl}urea
  • 1,3,3-Trimethyl-1-{1-[(3-methyl-1,2-oxazol-5-yl)methyl]piperidin-4-yl}urea
  • 1-[1-(5-Methoxypyrimidin-2-yl)piperidin-4-yl]-1,3,3-trimethylurea
  • 1-[1-(2-Cyclopropyl-6-methylpyrimidin-4-yl)piperidin-4-yl]-1,3,3-trimethylurea
  • 1,3,3-Trimethyl-1-{1-[(pyridin-4-yl)methyl]piperidin-4-yl}urea
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