2,2-Dimethyl-3-phenyl-4-(p-(beta-pyrrolidinoethoxy)phenyl)-7-methoxychromene hydrochloride

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Names

[ Name ]:
2,2-Dimethyl-3-phenyl-4-(p-(beta-pyrrolidinoethoxy)phenyl)-7-methoxychromene hydrochloride

[Synonym ]:
1-(2-(4-(2,2-Dimethyl-7-methoxy-3-phenyl-2H-1-benzopyran-4-yl)phenoxy)ethyl)pyrrolidine HCl
Pyrrolidine,1-(2-(4-(2,2-dimethyl-7-methoxy-3-phenyl-2H-1-benzopyran-4-yl)phenoxy)ethyl)-,hydrochloride
1-[2-[4-(7-methoxy-2,2-dimethyl-3-phenylchromen-4-yl)phenoxy]ethyl]pyrrolidine hydrochloride

Chemical & Physical Properties

[ Density]:
1.128g/cm3

[ Boiling Point ]:
584ºC at 760 mmHg

[ Molecular Formula ]:
C₃₀H₃₄ClNO₃

[ Molecular Weight ]:
492.04900

[ Flash Point ]:
155.9ºC

[ Exact Mass ]:
491.22300

[ PSA ]:
30.93000

[ LogP ]:
7.03980

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY0916000

CHEMICAL NAME :: Pyrrolidine, 1-(2-(4-(2,2-dimethyl-7-methoxy-3-phenyl-2H-1-benzopy ran-4-yl)phenoxy)ethy l)-, hydrochloride

CAS REGISTRY NUMBER :: 57897-49-1

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C30-H33-N-O3.Cl-H

MOLECULAR WEIGHT :: 492.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IJSIDW Indian Journal of Pharmaceutical Sciences. (Kalina, Santa Cruz (East), Bombay 400 029, India) V.40(2)- 1978- Volume(issue)/page/year: 49,43,1987 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 25 mg/kg

SEX/DURATION :: female 1-5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 19,276,1976

Related Compounds

benzyl N-(7-bromo-2-naphthyl)carbamate
4-(allyloxycarbonylamino)-2-bromo-3-fluoro-benzoic acid
(2R)-2-(allyloxycarbonylamino)-3-(2,4-dichlorophenyl)propanoic acid
benzyl (2S,4S)-2-(fluoromethyl)-4-methoxy-pyrrolidine-1-carboxylate
tert-butyl N-[(1S)-2-fluoro-1-methyl-ethyl]-N-methyl-carbamate
tert-butyl 6-chloro-3,5-dihydro-2H-pyrido[3,4-f][1,4]oxazepine-4-carboxylate
benzyl N-[(1R,2R)-2-hydroxycyclopentyl]-N-methyl-carbamate
benzyl N-[[(1R,3S)-3-hydroxy-2,2-dimethyl-cyclobutyl]methyl]carbamate
(2R)-3-(2-chloro-4-methyl-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid
2-(2,6-difluoro-4-methoxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)acetic acid

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