2,2-Dimethyl-3-phenyl-4-(p-(beta-pyrrolidinoethoxy)phenyl)-7-methoxychromene hydrochloride

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Names

[ CAS No. ]:
57897-49-1

[ Name ]:
2,2-Dimethyl-3-phenyl-4-(p-(beta-pyrrolidinoethoxy)phenyl)-7-methoxychromene hydrochloride

[Synonym ]:
1-(2-(4-(2,2-Dimethyl-7-methoxy-3-phenyl-2H-1-benzopyran-4-yl)phenoxy)ethyl)pyrrolidine HCl
Pyrrolidine,1-(2-(4-(2,2-dimethyl-7-methoxy-3-phenyl-2H-1-benzopyran-4-yl)phenoxy)ethyl)-,hydrochloride
1-[2-[4-(7-methoxy-2,2-dimethyl-3-phenylchromen-4-yl)phenoxy]ethyl]pyrrolidine hydrochloride

Chemical & Physical Properties

[ Density]:
1.128g/cm3

[ Boiling Point ]:
584ºC at 760 mmHg

[ Molecular Formula ]:
C30H34ClNO3

[ Molecular Weight ]:
492.04900

[ Flash Point ]:
155.9ºC

[ Exact Mass ]:
491.22300

[ PSA ]:
30.93000

[ LogP ]:
7.03980

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UY0916000
CHEMICAL NAME :
Pyrrolidine, 1-(2-(4-(2,2-dimethyl-7-methoxy-3-phenyl-2H-1-benzopy ran-4-yl)phenoxy)ethy l)-, hydrochloride
CAS REGISTRY NUMBER :
57897-49-1
LAST UPDATED :
198910
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C30-H33-N-O3.Cl-H
MOLECULAR WEIGHT :
492.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJSIDW Indian Journal of Pharmaceutical Sciences. (Kalina, Santa Cruz (East), Bombay 400 029, India) V.40(2)- 1978- Volume(issue)/page/year: 49,43,1987 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
25 mg/kg
SEX/DURATION :
female 1-5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 19,276,1976

Related Compounds

  • 4-(2,2-difluoroethyl)-5-(2,3-dimethylbutan-2-yl)-4H-1,2,4-triazole-3-thiol
  • 1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)but-2-enoyl]-2,3-dihydro-1H-indole-3-carboxylic acid
  • 3-[6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylheptanamido]-2-hydroxypropanoic acid
  • 2-(2-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentyl]acetamido}ethoxy)acetic acid
  • 3-{N-ethyl-2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentyl]acetamido}propanoic acid
  • 4-(2-ethoxyethyl)-5-(3-methylcyclobutyl)-4H-1,2,4-triazole-3-thiol
  • 5-[5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]-3-methylpentanoic acid
  • rac-(1R,2S)-2-{5-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1,3-oxazole-4-amido}cyclopentane-1-carboxylic acid
  • 2-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,3,3-trifluoro-N,2-dimethylpropanamido]oxy}acetic acid
  • 2-[(1-{2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1,3-thiazol-4-yl}-N-methylformamido)oxy]acetic acid
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