2-Methoxybenzoic acid

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Names

[ CAS No. ]:
579-75-9

[ Name ]:
2-Methoxybenzoic acid

[Synonym ]:
2-OMeC6H4COOH
2-methoxybenzoic
2-CARBOXYANISOLE
RARECHEM AL BO 0025
2-Anisic acid
EINECS 209-447-8
o-Anisic Acid
o-Anisc Acid
Methylsalicylic acid
O-METHYLSALICYLIC ACID
o-anisic
methoxybenzoic acid
2-Methoxy-benzoic acid
2-Methoxybenzoic acid
ortho-methoxybenzoic acid
Benzoic acid, 2-methoxy-
O-METHOXYBENZOIC ACID
ortho-anisic acid
MFCD00002431

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
279.9±13.0 °C at 760 mmHg

[ Melting Point ]:
98-100 °C(lit.)

[ Molecular Formula ]:
C₈H₈O₃

[ Molecular Weight ]:
152.147

[ Flash Point ]:
116.3±13.3 °C

[ Exact Mass ]:
152.047348

[ PSA ]:
46.53000

[ LogP ]:
1.50

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.546

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ4385000

CHEMICAL NAME :: o-Anisic acid

CAS REGISTRY NUMBER :: 579-75-9

BEILSTEIN REFERENCE NO. :: 0509929

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

WISWESSER LINE NOTATION :: QVR BO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle contraction or spasticity

REFERENCE :: BSRSA6 Bulletin de la Societe Royale des Sciences de Liege. (Societe Royale des Sciences de Liege, Universite de Liege, 15, Ave des Tilleuls, B-4000 Liege, Belgium) V.1- 1932- Volume(issue)/page/year: 47,202,1978

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2750 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle contraction or spasticity

REFERENCE :: BSRSA6 Bulletin de la Societe Royale des Sciences de Liege. (Societe Royale des Sciences de Liege, Universite de Liege, 15, Ave des Tilleuls, B-4000 Liege, Belgium) V.1- 1932- Volume(issue)/page/year: 47,202,1978

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,52,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 31,236,1982

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
BZ4385000

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

bromoanisole
Carbon dioxide
2-(2-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane
Ethanone, 2-hydroxy-1,2-bis(2-methoxyphenyl)-
Methyl 2-methoxybenzoate
carbon monoxide
Dimethyl sulfate
Salicylic acid
Anisole
2-Methylanisole

DownStream

Methyl 2-methoxybenzoate
Salicylic acid
Methyl salicylate
2-METHOXY-5-NITROBENZOIC ACID
2-methoxy-3-nitrobenzoic acid
2-Methoxy-4-nitrobenzoic acid
3-hydroxy-9H-9-xanthenone
5-Amino-2-methoxybenzoic acid
2-Chloro-6-methoxybenzoic acid
3-HYDROXY-6-METHOXYBENZOIC ACID

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

J. Med. Chem. 48 , 3269-79, (2005)

Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm...

Endogenous salicylic acid accumulation is required for chilling tolerance in cucumber (Cucumis sativus L.) seedlings.

Planta 240(4) , 687-700, (2014)

Salicylic acid (SA) is an important plant hormone, and its exogenous application can induce tolerance to multiple environmental stresses in plants. In this study, we examine the potential involvement ...

Purification and properties of gentisate 1,2-dioxygenase from Moraxella osloensis.

J. Bacteriol. 121(3) , 794-9, (1975)

Gentisate:oxygen 1,2-oxidoreductase (decyclizing) (EC 1.13.11.4; gentisate 1,2-dioxygenase) from Moraxella osloensis was purified to homogeneity as shown by polyacrylamide gel electrophoresis. The enz...