DICHLORO(4-METHYL-o-PHENYLENEDI-AMMINE)PLATINUM(II)

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Names

[ CAS No. ]:
57948-13-7

[ Name ]:
DICHLORO(4-METHYL-o-PHENYLENEDI-AMMINE)PLATINUM(II)

[Synonym ]:
dichloro-1,3 methoxycarbonylhydrazono-2 propane

Chemical & Physical Properties

[ Boiling Point ]:
262.3ºC at 760 mmHg

[ Molecular Formula ]:
C7H8Cl2N2Pt

[ Molecular Weight ]:
386.13600

[ Flash Point ]:
132.1ºC

[ Exact Mass ]:
384.97100

[ PSA ]:
24.06000

[ LogP ]:
3.39990

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TP2497220
CHEMICAL NAME :
Platinum (II), dichloro(4-methyl-o-phenylenediammine)-
CAS REGISTRY NUMBER :
57948-13-7
LAST UPDATED :
199712
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H10-Cl2-N2-Pt
MOLECULAR WEIGHT :
388.18
WISWESSER LINE NOTATION :
ZR BZ D1 &G-PT-G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
23 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
2500 nmol/L
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,459,1980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Potassium tetrachloroplatinate(II)
  • 3,4-Diaminotoluene

DownStream

Related Compounds

  • 2-((3-Bromobenzyl)amino)-2-oxoethyl 4-methylbenzoate
  • [Methyl(3-methylphenyl)carbamoyl]methyl 5-bromopyridine-3-carboxylate
  • 2-[(2-Chloro-5-fluorophenyl)amino]-2-oxoethyl 5-bromopyridine-3-carboxylate
  • 2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-oxoethyl 5-bromopyridine-3-carboxylate
  • 2-[(3-Methylbenzyl)amino]-2-oxoethyl 5-bromopyridine-3-carboxylate
  • 2-[(3,4-Dimethylbenzyl)amino]-2-oxoethyl 5-bromopyridine-3-carboxylate
  • 2-[(4-Ethylbenzyl)amino]-2-oxoethyl 5-bromopyridine-3-carboxylate
  • 2-{[1-(4-Methylphenyl)ethyl]amino}-2-oxoethyl 5-bromopyridine-3-carboxylate
  • 2-{[1-(4-Methoxyphenyl)ethyl]amino}-2-oxoethyl 5-bromopyridine-3-carboxylate
  • 2-[(2,4-Difluorobenzyl)amino]-2-oxoethyl 5-bromopyridine-3-carboxylate
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