Miltefosine
Suppliers
Names
[ CAS No. ]:
58066-85-6
[ Name ]:
Miltefosine
[Synonym ]:
Miltex
Hexadecyl 2-(trimethylammonio)ethyl phosphate
2-[[(Hexadecyloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethylethanaminium Inner Salt
Ethanaminium, 2-[[(hexadecyloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, inner salt
MIL
Miltefosine
hexadecyl 2-(trimethylazaniumyl)ethyl phosphate
HPC [VAN]
Miltefosine [BAN:INN]
hexadecylphosphocholine
Impavido
MFCD00133396
Hexadecyl 2-(N,N,N-trimethylamino)ethyl phosphate
Chemical & Physical Properties
[ Melting Point ]:
232-234ºC
[ Molecular Formula ]:
C21H46NO4P
[ Molecular Weight ]:
407.568
[ Exact Mass ]:
407.316437
[ PSA ]:
68.40000
[ LogP ]:
3.58
[ Storage condition ]:
room temp
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KH2890000
- CHEMICAL NAME :
- Ethanaminium, 2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimet hyl-, hydroxide, inner salt
- CAS REGISTRY NUMBER :
- 58066-85-6
- BEILSTEIN REFERENCE NO. :
- 3690495
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C21-H46-N-O4-P
- MOLECULAR WEIGHT :
- 407.65
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 246 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- LPDSAP Lipids. (American Oil Chemists' Soc., POB 5037, Stn. A., Champaign, IL 61820) V.1- 1966- Volume(issue)/page/year: 22,930,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 560 mg/kg/4W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- REFERENCE :
- LPDSAP Lipids. (American Oil Chemists' Soc., POB 5037, Stn. A., Champaign, IL 61820) V.1- 1966- Volume(issue)/page/year: 22,930,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 510 mg/kg/11D-I
- TOXIC EFFECTS :
- Gastrointestinal - alteration in gastric secretion Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- REFERENCE :
- CCPHDZ Cancer Chemotherapy and Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1978- Volume(issue)/page/year: 32,437,1993
Safety Information
[ Symbol ]:
GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H334
[ Precautionary Statements ]:
P261-P301 + P310-P342 + P311
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
22-43
[ Safety Phrases ]:
36/37
[ RIDADR ]:
UN 2811 6.1 / PGIII
[ RTECS ]:
KH2890000
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