Cinromide

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Names

[ CAS No. ]:
58473-74-8

[ Name ]:
Cinromide

[Synonym ]:
MFCD00075351
cinromide
trans 3-bromo-N-ethylcinnamamide
Cinromide (usan/inn)
m-Bromo-N-ethylcinnamamide
trans-3-Brom-N-ethylzimtsaeureamid
(e)-3-(3-bromophenyl)-n-ethyl-2-propenamide

Chemical & Physical Properties

[ Density]:
1.369g/cm3

[ Boiling Point ]:
417.5ºC at 760mmHg

[ Melting Point ]:
89-91ºC(lit.)

[ Molecular Formula ]:
C11H12BrNO

[ Molecular Weight ]:
254.12300

[ Flash Point ]:
206.3ºC

[ Exact Mass ]:
253.01000

[ PSA ]:
29.10000

[ LogP ]:
2.98930

[ Index of Refraction ]:
1.591

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UC6314000
CHEMICAL NAME :
2-Propenamide, 3-(3-bromophenyl)-N-ethyl-, (E)-
CAS REGISTRY NUMBER :
58473-74-8
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C11-H12-Br-N-O
MOLECULAR WEIGHT :
254.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4437 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 33,741,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2277 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 33,741,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
660 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 33,741,1981

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
UC6314000

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethylamine
  • (E)-ethyl 3-(3-bromophenyl)acrylate

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Prediction of steady-state behavior of metabolite from dosing of parent drug.

J. Pharm. Sci. 69(5) , 610-2, (1980)

Variability in the determination of fraction metabolized in a triangular metabolic problem and its resolution with stable isotope methodology.

J. Pharm. Sci. 73(2) , 285-7, (1984)

Simultaneous determination of the anticonvulsants, cinromide (3-bromo-n-ethylcinnamamide), 3-bromocinnamamide, and carbamazepine in plasma by high-performance liquid chromatography.

J. Chromatogr. A. 163(2) , 187-93, (1979)

A high-performance liquid chromatographic method is described for monitoring plasma concentrations of cinromide (3-bromo-N-ethylcinnamamide) and its de-ethylated metabolite. Carbamazepine levels can b...


More Articles

Related Compounds

  • cinromide
  • Pioglitazone hydrochloride, (R)-
  • Methyl 2-methyl-1,3-thiazole-5-carboximidate
  • 4,5-Dichloro-2-(3-methoxypropyl)pyridazin-3(2H)-one
  • 1,3-Dihydro-5-[4-(4-pyridinyl)-6-quinolinyl]-2h-indol-2-one
  • Bis(2,4-di-tert-butylphenyl) phosphonate
  • 3-(Azetidin-3-yl)pyridazine
  • 1-Benzhydryl-3-benzylazetidine
  • Chloramine-T dihydrate
  • [4-(Piperazine-1-carbonyl)phenyl]boronic acid
  • 1-(3-{6-[2-(2,4-Dichloro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenyl)-cyclopentanecarboxylic acid
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