Urea,N-(2-chloroethyl)-N'-b-D-glucopyranosyl-N-nitroso-

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Names

[ CAS No. ]:
58484-07-4

[ Name ]:
Urea,N-(2-chloroethyl)-N'-b-D-glucopyranosyl-N-nitroso-

[Synonym ]:
ganu

Chemical & Physical Properties

[ Density]:
1.85g/cm3

[ Molecular Formula ]:
C9H16ClN3O7

[ Molecular Weight ]:
313.69200

[ Exact Mass ]:
313.06800

[ PSA ]:
151.92000

[ Index of Refraction ]:
1.664

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YS4981000
CHEMICAL NAME :
Urea, 1-(2-chloroethyl)-3-(beta-D-glucopyranosyl)-1-nitroso -
CAS REGISTRY NUMBER :
58484-07-4
LAST UPDATED :
199112
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C9-H16-Cl-N3-O7
MOLECULAR WEIGHT :
313.73
WISWESSER LINE NOTATION :
T6OTJ BMVNNO&2G CQ DQ EQ F1Q -B,D-GLU

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
LD10 - Lethal Dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
10 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 37,783,1977

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-(2-chloroethyl)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]urea
  • beta-D-Glucopyranosylamine
  • Diethyl ether
  • o-nitrophenyl N-(2-chloroethyl)-N-nitrosocarbamate
  • Carbon dioxide

DownStream

Related Compounds

  • 4-(2,4-Difluorophenyl)-8-(2-methoxyphenyl)-7-oxido-1,7-naphthyridin-7-ium
  • 3,5-Dimethyl-4-(prop-1-en-2-yl)phenol
  • 3-Methylnonane-4,6-dione
  • 3-(3-chloro-5-ethoxy-4-methoxyphenyl)-2-cyano-N-(4-sulfamoylphenyl)prop-2-enamide
  • 4-[2-Cyano-3-(3,4-dimethoxyphenyl)prop-2-enamido]benzoic acid
  • (2S)-1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-2-methyl-N-(1,3-thiazol-2-yl)pyrrolidine-2-carboxamide
  • 5-[(Cyclopropylamino)sulfonyl]-2-thiopheneacetic acid
  • Bis-OTBS-6-[(3-methyl-2-buten-1-yl)oxy]phenyl]ethanone
  • 2-(4-bromo-5-formyl-2-methoxyphenoxy)-N-[2-(3-chlorophenyl)ethyl]acetamide
  • methyl (3S,4R)-1-benzyl-4-methylpyrrolidine-3-carboxylate
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