KU55933 (ATM Kinase Inhibitor)

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Names

[ CAS No. ]:
587871-26-9

[ Name ]:
KU55933 (ATM Kinase Inhibitor)

[Synonym ]:
2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one
2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one
2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one
KU 55933
2-Thianthren-1-yl-6-morpholin-4-yl-pyran-4-one
KU55933
ATM Kinase Inhibitor
4H-Pyran-4-one, 2-(4-morpholinyl)-6-(1-thianthrenyl)-
KU-55933

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
628.0±55.0 °C at 760 mmHg

[ Melting Point ]:
229.98° C

[ Molecular Formula ]:
C21H17NO3S2

[ Molecular Weight ]:
395.495

[ Flash Point ]:
333.6±31.5 °C

[ Exact Mass ]:
395.064972

[ PSA ]:
93.28000

[ LogP ]:
6.13

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.714

[ Storage condition ]:
Desiccate at -20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-Thianthrenylboronic acid
  • 2-chloro-6-morpholinopyran-4-one
  • 4,4-dichloro-1-(morpholin-4-yl)but-3-ene-1,2-dione
  • 4-chloro-4-(2,2,2-trichloroethyl)oxetan-2-one

DownStream

Articles

TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint.

BMC Mol. Biol. 17 , 3, (2016)

The Tousled like kinase 1B (TLK1B) is critical for DNA repair and survival of cells. Upon DNA damage, Chk1 phosphorylates TLK1B at S457 leading to its transient inhibition. Once TLK1B regains its kina...


More Articles

Related Compounds

  • PDGFR Tyrosine Kinase Inhibitor III
  • p38 MAP Kinase Inhibitor IV
  • Pim-1 kinase inhibitor 1
  • p38 MAP Kinase Inhibitor III
  • Dual BET-Kinase inhibitor 3
  • PDGFR Tyrosine Kinase Inhibitor V
  • Furo[2,3-b]pyridin-3(2H)-one, 2-(2,4-dinitrophenyl)hydrazone
  • Benzenamine, N-1,3-dithietan-2-ylidene-4-(2-propyn-1-yloxy)-
  • 2-Benzoxazolecarboxylic acid, 5-fluoro-, 2-ethoxyethyl ester
  • I(2)-D-Glucopyranose, 1-thio-, 1-[N-(sulfooxy)-6-heptenimidate]
  • rel-1-(1R,2R,4S)-Bicyclo[2.2.1]hept-2-yl-4-chloro-1-butanone
  • (2Z)-N1-(4-Chlorophenyl)-N4-(2-hydroxyethyl)-2-butenediamide
  • 2-Pyridinecarboxaldehyde, 4-[5-(3-oxetanyloxy)-2-pyrazinyl]-
  • Benzenemethanamine, I+/--(1,1-dimethylethyl)-3-ethoxy-I+/--methyl-
  • Alanine, N-[N-(N-formylglycyl)glycyl]-3-phenyl-, ethyl ester
  • 2-[(2-Methyl-4-nitrophenyl)amino]-1H-isoindole-1,3(2H)-dione
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