1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline hydrochloride

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Names

[ CAS No. ]:
5884-22-0

[ Name ]:
1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline hydrochloride

[Synonym ]:
6,7-Dimethoxy-1-veratryl-3,4-dihydro-isochinolin,Hydrochlorid
DIHYDROALKALI HYDROCHLORIDE
isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-, hydrochloride (1:1)
Isoquinolinium, 1-[(3,4-dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-, chloride (1:1)
3,4-dihydropapaverine hydrochloride
1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinolinium chloride
Dihydropapaverinehydrochloride
6,7-dimethoxy-1-veratryl-3,4-dihydro-isoquinoline,hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
482.6ºC at 760mmHg

[ Melting Point ]:
202ºC

[ Molecular Formula ]:
C20H24ClNO4

[ Molecular Weight ]:
377.862

[ Flash Point ]:
196.9ºC

[ Exact Mass ]:
377.139374

[ PSA ]:
49.28000

[ LogP ]:
3.54650

[ Index of Refraction ]:
1.554

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NW7628980
CHEMICAL NAME :
Isoquinoline, 3,4-dihydro-6,7-dimethoxy-1-veratryl-, hydrochloride
CAS REGISTRY NUMBER :
5884-22-0
LAST UPDATED :
198609
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H23-N-O4.Cl-H
MOLECULAR WEIGHT :
377.90

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
APPBDI Acta Physiologica et Pharmacologica Bulgarica. (Izdatelstvo na Bulgarskata Akademiya na Naukite, ul. Akad. G. Bonchev, 1113 Sofia, Bulgaria) V.1- 1974- Volume(issue)/page/year: 5(3),82,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 5,69,1950

Safety Information

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-(3,4-Dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide
  • N-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dimethoxybenzamide
  • 3,4-Dimethoxyphenethylamine
  • 3,4-Dimethoxyphenylacetic acid

DownStream

  • (+/-)-Tetrahydropapaverine

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%