2,5-Lutidine

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Names

[ CAS No. ]:
589-93-5

[ Name ]:
2,5-Lutidine

[Synonym ]:
Lutidine
MFCD00006343
2,5-dimythilpyridine
2,5-Lutidine
Pyridine,2,5-dimethyl
EINECS 209-666-9
2,5-Dimethylpyridine
Pyridine, 2,5-dimethyl-
2,6-lutidine
2-methyl-5-methylpyridine
2,5-dimethyl pyridine
2,4-DIOXO-1,2,3,4-TETRAHYDRO-QUINAZOLINE-6-SULFONYL CHLORIDE

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
158.0±0.0 °C at 760 mmHg

[ Melting Point ]:
−15 °C(lit.)

[ Molecular Formula ]:
C7H9N

[ Molecular Weight ]:
107.153

[ Flash Point ]:
47.8±0.0 °C

[ Exact Mass ]:
107.073502

[ PSA ]:
12.89000

[ LogP ]:
1.65

[ Vapour Pressure ]:
3.5±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.502

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OK9625000
CHEMICAL NAME :
2,5-Lutidine
CAS REGISTRY NUMBER :
589-93-5
LAST UPDATED :
199710
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C7-H9-N
MOLECULAR WEIGHT :
107.17
WISWESSER LINE NOTATION :
T6NJ B1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 33(10-12),341,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
670 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 33(10-12),341,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
827 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 33(10-12),341,1968 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1084 mg/kg/9W-I
TOXIC EFFECTS :
Blood - change in clotting factors Blood - thrombocytopenia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(12),18,1968
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1810 ug/kg/26W-I
TOXIC EFFECTS :
Blood - change in clotting factors Blood - changes in other cell count (unspecified) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(12),18,1968

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H302 + H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R10;R20/21/22;R36/37/38

[ Safety Phrases ]:
S16-S26-S36/37/39-S45

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
OK9625000

[ Packaging Group ]:
III

[ Hazard Class ]:
3.2

[ HS Code ]:
2933399090

Synthetic Route

Precursor & DownStream

Precursor

  • 2,5-dimethylpyridine 1-oxide
  • 2(3H)-Furanone,3-acetyldihydro-5-methyl-
  • Aminoform
  • paraldehyde
  • 5-[(diethylmethylsilyl)oxy]-2-[1-[(diethylmethylsilyl)oxy]ethylidene]-4-methyl-4-pentenoic acid diethylmethylsilyl ester
  • acrolein
  • 2-Bromo-5-picoline
  • methyl iodide
  • 3-Mepy
  • 1-Octanol

DownStream

  • Ethyl 5-methylpicolinate
  • Methyl 5-(bromomethyl)picolinate
  • 5-Methylpicolinic acid
  • 6-Methylnicotinic acid
  • 2,5-Pyridinedicarboxylic acid
  • 5-Methylpicolinaldehyde
  • 2-Methyl-5-formylpyridine
  • 4-Methylnicotinonitrile
  • 2-Pyridinecarboxamide,5-methyl-(9CI)
  • Nicotinic acid

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Spectroscopic properties, NLO, HOMO-LUMO and NBO analysis of 2,5-Lutidine.

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Related Compounds

  • 2,5-lutidine
  • 2,5-lutidine N-oxide
  • 2,5-LUTIDINE,3-AMINO
  • 4-amino-2,5-lutidine
  • 3-Bromo-2,5-lutidine
  • 4-Amino-2,5-lutidine 1-oxide
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
  • N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine