Laurolitsine
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Names
[ CAS No. ]:
5890-18-6
[ Name ]:
Laurolitsine
[Synonym ]:
Norisoboidine
(6aS)-1,10-Dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol
Norboldine
laurolistine
LAUROLITSINE
4H-Dibenzo[de,g]quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-, (6aS)-
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
553.0±50.0 °C at 760 mmHg
[ Melting Point ]:
138-140ºC
[ Molecular Formula ]:
C18H19NO4
[ Molecular Weight ]:
313.348
[ Flash Point ]:
288.3±30.1 °C
[ Exact Mass ]:
313.131409
[ PSA ]:
70.95000
[ LogP ]:
1.43
[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C
[ Index of Refraction ]:
1.643
[ Storage condition ]:
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RB5935000
- CHEMICAL NAME :
- 6a-alpha-Noraporphine-2,9-diol, 1,10-dimethoxy-
- CAS REGISTRY NUMBER :
- 5890-18-6
- LAST UPDATED :
- 198208
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C18-H19-N-O4
- MOLECULAR WEIGHT :
- 313.38
- WISWESSER LINE NOTATION :
- T C6666 1A Q KM&TT&J EO1 FQ PQ QO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 450 mg/kg
- TOXIC EFFECTS :
- Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 170 mg/kg
- TOXIC EFFECTS :
- Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980