1,2,3,4-TETRAHYDRONORHARMANE HYDROCHLORIDE

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Names

[ CAS No. ]:
58911-02-7

[ Name ]:
1,2,3,4-TETRAHYDRONORHARMANE HYDROCHLORIDE

[Synonym ]:
Tryptoline hydrochloride
EINECS 261-493-8
Tetrahydronorharman
1,2,3,4-tetrahydronorharmane hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
351.6ºC at 760 mmHg

[ Molecular Formula ]:
C11H13ClN2

[ Molecular Weight ]:
208.68700

[ Flash Point ]:
166.5ºC

[ Exact Mass ]:
208.07700

[ PSA ]:
27.82000

[ LogP ]:
2.94440

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV0710000
CHEMICAL NAME :
9H-Pyrido(3,4-b)indole, 1,2,3,4-tetrahydro-, hydrochloride
CAS REGISTRY NUMBER :
58911-02-7
LAST UPDATED :
199712
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C11-H12-N2.Cl-H
MOLECULAR WEIGHT :
208.71
WISWESSER LINE NOTATION :
T B656 EM HMT&&J &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
290 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 2,525,1929
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 2,525,1929
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 2,525,1929
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Behavioral - ataxia
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 2,525,1929
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 2,525,1929

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2,3,4,9-Tetrahydro-2-(2-phenylmethyl)-1H-pyrido[3,4-b]indole hydrochloride

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 1-Hydroxymethyl-1,2,3,4-tetrahydronorharmane hydrochloride
  • 1-(3,4,5-Trimethoxybenzoyloxymethyl)-2-ethyl-1,2,3,4-tetrahydronorharmane hydrochloride
  • methyl 1-methyl-6-phenylmethoxy-2,3,4,9-tetrahydropyrido[3,4-b]indole-1-carboxylate
  • TNCA
  • 1,2,3,4-Tetrahydrophthalazine hydrochloride
  • 1,2,3,4-tetrahydro-5-isoquinolinecarbonitrile hydrochloride
  • (3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-methyl-3-nitrophenyl)propanoic acid
  • 3-(6-Fluoropyridin-3-yl)-5-methyl-1,2-oxazole-4-carboxylic acid
  • 3-(2,6-Dimethylpiperidin-1-yl)cyclobutane-1-carboxylic acid
  • 3-[4-(2-Methylpropyl)piperazin-1-yl]cyclobutane-1-carboxylic acid
  • (3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-methyl-3-nitrophenyl)propanoic acid
  • 3-(2,2,6,6-Tetramethylmorpholin-4-yl)cyclobutane-1-carboxylic acid
  • 2-(3-{[(Benzyloxy)carbonyl]amino}-1-[(tert-butoxy)carbonyl]-5-methylpyrrolidin-3-yl)acetic acid
  • 3,4-Bis({[(tert-butoxy)carbonyl]amino})pentanoic acid
  • 5-({[2-(Ethylsulfanyl)ethyl]sulfanyl}methyl)furan-2-carboxylic acid
  • 5-({[3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propyl]sulfanyl}methyl)furan-2-carboxylic acid
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