Cyclizine dihydrochloride

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Names

[ CAS No. ]:
5897-18-7

[ Name ]:
Cyclizine dihydrochloride

[Synonym ]:
Cyclizine dihydrochloride
Cyclizine 2HCl

Chemical & Physical Properties

[ Molecular Formula ]:
C18H23ClN2

[ Molecular Weight ]:
302.84200

[ Exact Mass ]:
302.15500

[ PSA ]:
6.48000

[ LogP ]:
3.70120

[ Storage condition ]:
-20℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL6490000
CHEMICAL NAME :
Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride
CAS REGISTRY NUMBER :
5897-18-7
LAST UPDATED :
199606
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C18-H22-N2.2Cl-H
MOLECULAR WEIGHT :
339.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
69 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - other changes
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 46,279,1957 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
11928 mg/kg/12W-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 112,297,1954

Related Compounds

  • Cyclizine Hydrochloride
  • CYCLIZINE LACTATE
  • CHLOROETHYLCLONIDINE DIHYDROCHLORIDE
  • Elacestrant dihydrochloride
  • Furosine dihydrochloride
  • Sardomozide dihydrochloride
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  • N-(2,3-dimethylcyclohexyl)-4-(4-methylphenyl)-4-oxobutanamide
  • 5-bromo-N-(2-methyl-2-morpholin-4-ylpropyl)furan-2-carboxamide
  • 3H-benzimidazol-5-yl-[4-(3-methoxyphenyl)piperazin-1-yl]methanone
  • 2-phenoxy-N-(2-piperidin-1-ylphenyl)butanamide
  • 3-chloro-N-(pyridin-3-ylmethyl)adamantane-1-carboxamide
  • 2-chloro-N-{3-[2-cyano-2-(pyrrolidine-1-carbonyl)eth-1-en-1-yl]phenyl}benzamide
  • 1-(4-Methoxyphenyl)-3-(1,2,3,4-tetrahydronaphthalen-1-yl)urea
  • chaetomugilin D
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