Cyclizine dihydrochloride

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Names

[ CAS No. ]:
5897-18-7

[ Name ]:
Cyclizine dihydrochloride

[Synonym ]:
Cyclizine dihydrochloride
Cyclizine 2HCl

Chemical & Physical Properties

[ Molecular Formula ]:
C18H23ClN2

[ Molecular Weight ]:
302.84200

[ Exact Mass ]:
302.15500

[ PSA ]:
6.48000

[ LogP ]:
3.70120

[ Storage condition ]:
-20℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL6490000
CHEMICAL NAME :
Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride
CAS REGISTRY NUMBER :
5897-18-7
LAST UPDATED :
199606
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C18-H22-N2.2Cl-H
MOLECULAR WEIGHT :
339.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
69 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - other changes
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 46,279,1957 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
11928 mg/kg/12W-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 112,297,1954

Related Compounds

  • Cyclizine Hydrochloride
  • CYCLIZINE LACTATE
  • CHLOROETHYLCLONIDINE DIHYDROCHLORIDE
  • Elacestrant dihydrochloride
  • Furosine dihydrochloride
  • Sardomozide dihydrochloride
  • E-ethyl 5-(2-(dimethylamino)vinyl)-2,4-dinitrobenzoate
  • 2-Bromo-1-(2-fluoro-5-methylphenyl)ethanone
  • Methyl 2-cyano-3,3,3-trifluoropropanoate
  • D-Ribitol, 2,5-dideoxy-2,5-episeleno-1-O-(phenylmethyl)-, diacetate
  • 1,3,5-Benzenetriethanol
  • (R,E)-N-(1-(Naphthalen-1-yl)ethylidene)-1-phenylethanamine
  • 3-Indolizinol, 3-acetate
  • 1-(2-Thienylmethyl)-cyclobutanecarboxaldehyde
  • methyl 3-ethoxy-5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]azepine-5-carboxylate
  • (R)-1-(naphthalen-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol
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