p-chloromercuribenzoic acid
Names
[ CAS No. ]:
59-85-8
[ Name ]:
p-chloromercuribenzoic acid
[Synonym ]:
MFCD00002526
4-Carboxy-phenylquecksilber(1+),Chlorid
PARA-CHLOROMERCURIBENZOICACID
P-CMB
P-CHLOROMERCURIBENZOIC ACID
4-(chloromercuri) benzoic acid
p-Chlormercuribenzoic Acid
4-Chloromercurio-benzoesaeure
EINECS 200-442-6
p-(chloromercuri)-benzoicaci
p-chloromercury(II)benzoic acid
p-chloro-mercuricbenzoicacid
4-CHLOROMERCURIBENZOIC ACID
usafd-3
P-CMBA
4-carboxy-phenylmercury (1+),chloride
Chemical & Physical Properties
[ Melting Point ]:
287 °C (dec.)(lit.)
[ Molecular Formula ]:
C7H5ClHgO2
[ Molecular Weight ]:
357.15600
[ Exact Mass ]:
357.96800
[ PSA ]:
37.30000
[ LogP ]:
1.24640
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OV8050000
- CHEMICAL NAME :
- Mercury, (p-carboxyphenyl)chloro-
- CAS REGISTRY NUMBER :
- 59-85-8
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 22
- MOLECULAR FORMULA :
- C7-H4-Cl-Hg-O2.H
- MOLECULAR WEIGHT :
- 357.16
- WISWESSER LINE NOTATION :
- QVR D-HG-G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 *** REVIEWS *** ACGIH TLV-TWA 0.1 mg(Hg)/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.05 mg(Hg)/m3 DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,22,1973 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.05 mg(Hg)/m3;Skin JAN 1993 OEL-BELGIUM:TWA 0.05 mg(Hg)/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.05 mg(Hg)/m3 JAN 1993 OEL-FINLAND:TWA 0.05 mg(Hg)/m3 JAN 1993 OEL-FRANCE:TWA 0.05 mg(Hg)/m3 JAN 1993 OEL-GERMANY:TWA 0.01 ppm (0.1 mg(Hg)/m3) JAN 1993 OEL-HUNGARY:TWA 0.02 mg(Hg)/m3;STEL 0.04 mg(Hg)/m3 JAN 1993 OEL-JAPAN:TWA 0.05 mg(Hg)/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.05 mg(Hg)/m3 JAN 1993 OEL-POLAND:TWA 0.01 mg(Hg)/m3 JAN 1993 OEL-RUSSIA:TWA 0.05 mg(Hg)/m3;STEL 0.01 mg(Hg)/m3 JAN 1993 OEL-SWEDEN:TWA 0.05 mg(Hg)/m3 JAN 1993 OEL-THAILAND:STEL 0.05 mg(Hg)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
Safety Information
[ Symbol ]:
GHS06, GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300 + H310 + H330-H373-H410
[ Precautionary Statements ]:
P260-P273-P280-P301 + P310 + P330-P302 + P352 + P310-P304 + P340 + P310
[ Hazard Codes ]:
T+,N
[ Risk Phrases ]:
R26/27/28;R33
[ Safety Phrases ]:
S13-S28-S36-S45-S60-S61
[ RIDADR ]:
UN 2025 6.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
OV8050000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)
Precursor & DownStream
Precursor
DownStream
Articles
Nat. Chem. Biol. 5 , 765-71, (2009)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...
Biol. Pharm. Bull. 35(11) , 2088-91, (2012)
Recently, we have found that pressure-induced hemolysis is enhanced by inhibiting water transport via aquaporin-1 (AQP1), as seen in p-chloromercuribenzoate (pCMB)-treated erythrocytes. So, using this...
Antimicrob. Agents Chemother. 53 , 5279-83, (2009)
In this study, application of a dual absorbance/fluorescence assay to a chemical library screen identified several previously unknown inhibitors of mycobacteria. In addition, growth conditions had a s...