Lorzafone

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Names

[ CAS No. ]:
59179-95-2

[ Name ]:
Lorzafone

[Synonym ]:
LORZAFONE
Lorzafona [Spanish]
Lorzafone anhydrous
45-OO88S
Lorzafonum [Latin]
glycyl-n-[4-chloro-2-(2-chlorobenzoyl)phenyl]-n-methylglycinamide
45-0088S
2-(2-Chlorobenzoyl)-4-chloro-N-methyl-N'-glycylglycinanilide
Glycinamide,glycyl-N-(4-chloro-2-(2-chlorobenzoyl)phenyl)-N-methyl

Chemical & Physical Properties

[ Boiling Point ]:
671.4ºC at 760 mmHg

[ Molecular Formula ]:
C18H17Cl2N3O3

[ Molecular Weight ]:
394.25200

[ Flash Point ]:
359.9ºC

[ Exact Mass ]:
393.06500

[ PSA ]:
92.50000

[ LogP ]:
3.35330

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MB7526510
CHEMICAL NAME :
Glycinamide, N-(4-chloro-2-(2-chlorobenzoyl)phenyl)-glycyl-N-methy l-, hydrate
CAS REGISTRY NUMBER :
59179-95-2
LAST UPDATED :
199103
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C18-H17-Cl2-N3-O3.H2-O
MOLECULAR WEIGHT :
412.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Behavioral - antianxiety
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,20,1981

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(phthalylglycyl)glycinanilide
  • 4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-[(benzyloxycarbonyl)glycyl]glycinanilide
  • 4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(iodoacetyl)glycinanilide
  • 4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-glycinanilide hydrobromide
  • 2,5-DICHLORO-2-(METHYLAMINO)BENZOPHENONE
  • 4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(chloroacetyl)glycinanilide
  • ethyl 5-chloro-3-(o-chlorophenyl)-indole-2-carboxylate

DownStream

Related Compounds

  • Lorzafone [USAN:INN]
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 2-(4-methoxy-1H-1,2,3-benzotriazol-1-yl)propan-1-ol
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • N-[2-(aminomethyl)pyridin-3-yl]-2,3,3-trimethylbutanamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine