bromoethene

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Names

[ CAS No. ]:
593-60-2

[ Name ]:
bromoethene

[Synonym ]:
Vinyl bromide
MFCD00000183
cis-vinyl bromide
trans vinyl bromide
bromoethylene
EINECS 209-800-6

Chemical & Physical Properties

[ Density]:
1.517 g/mL at 25 °C(lit.)

[ Boiling Point ]:
16 °C750 mm Hg(lit.)

[ Melting Point ]:
−139 °C(lit.)

[ Molecular Formula ]:
C2H3Br

[ Molecular Weight ]:
106.94900

[ Flash Point ]:
1 °F

[ Exact Mass ]:
105.94200

[ LogP ]:
1.52480

[ Vapour density ]:
3.8 (15 °C, vs air)

[ Vapour Pressure ]:
1551 mm Hg ( 37.8 °C)

[ Index of Refraction ]:
n20/D 1.410

[ Stability ]:
Stable, but may polymerize in sunlight. Reacts violently with all types of oxidizer. Incompatible with strong oxidizing agents, peroxides, copper, copper alloys, plastics. Highly flammable.

[ Water Solubility ]:
insoluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KU8400000
CHEMICAL NAME :
Ethylene, bromo-
CAS REGISTRY NUMBER :
593-60-2
BEILSTEIN REFERENCE NO. :
1361370
LAST UPDATED :
199712
DATA ITEMS CITED :
35
MOLECULAR FORMULA :
C2-H3-Br
MOLECULAR WEIGHT :
106.96
WISWESSER LINE NOTATION :
E1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50000 ppm/7H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10000 ppm/7H/4W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
250 ppm/6H/26W-I
TOXIC EFFECTS :
Cardiac - changes in heart weight Liver - changes in liver weight
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 ppm/6H/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors
TYPE OF TEST :
TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 ppm
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Blood - lymphoma, including Hodgkin's disease
TYPE OF TEST :
TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
52 ppm/6H/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors

MUTATION DATA

TEST SYSTEM :
Rodent - rat
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 47,71,1981 *** REVIEWS *** ACGIH TLV-Suspected human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 22 mg/m3 (5 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,133,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,133,1986 IARC Cancer Review:Group 2A IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 22,31,1980 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 250 ppm (1100 mg/m3) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,31,1972 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (20 mg/m3);Carcinogen JAN 1993 OEL-BELGIUM:TWA 5 ppm (22 mg/m3);Carcinogen JAN 1993 OEL-DENMARK:TWA 5 ppm (20 mg/m3);Carcinogen JAN 1993 OEL-FINLAND:TWA 5 ppm (20 mg/m3);STEL 10 ppm (40 mg/m3);Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (20 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (20 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO VINYL BROMIDE-air:CA lowest feasible concentration REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84575 No. of Facilities: 11 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 357 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84575 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1822 (estimated) No. of Female Employees: 272 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302-H319-H335-H350

[ Supplemental HS ]:
May form explosive peroxides.

[ Precautionary Statements ]:
P201-P210-P280-P308 + P313-P370 + P378-P403 + P235

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F+:Highlyflammable;T:Toxic;

[ Risk Phrases ]:
R45;R12

[ Safety Phrases ]:
S53-S9-S16-S29-S33-S45

[ RIDADR ]:
UN 1993 3/PG 1

[ WGK Germany ]:
3

[ RTECS ]:
KU8400000

[ Hazard Class ]:
2.1

Synthetic Route

Precursor & DownStream

Precursor

  • 1,2-Dibromoethane
  • Acetylene
  • 1,2-DIBROMOETHYLTRICHLOROSILANE
  • dibromoethane
  • ethene
  • (6-iodohex-1-yn-1-yl)benzene
  • allyl bromide
  • (Z)-2-(2-oxoindolin-3-ylidene)acetic acid
  • 1,1,2-TRIBROMOETHANE
  • 1-Bromo-2-chloroethane

DownStream

  • ethenyl-dimethyl-trimethylsilylsilane
  • 3-Phenylpropene-3-ol
  • Benzene,[1-[(trimethylsilyl)oxy]-2-propen-1-yl]-
  • N-Vinylphthalimide
  • Propiolic acidd
  • 2-Butynedioic acid
  • dibromoethane
  • 1,2-Dibromoethane
  • 4-Fluorostyrene
  • 4,4'-Difluorobiphenyl

Articles

Reactivity in nucleophilic vinylic substitution (S(N)V):S(N)Vπ versus S(N)Vσ mechanistic dichotomy.

J. Org. Chem. 78(17) , 8574-84, (2013)

The intrinsic electronic factors that determine reactivity in prototypical identity nucleophilic vinylic substitution reactions, X(-) + ViX → XVi + X(-) (Vi = vinyl), have been studied by performing q...

Asymmetric synthesis of enantioenriched (+)-elaeokanine A.

J. Org. Chem. 71(15) , 5674-8, (2006)

The key transformation in the total synthesis of (+)-elaeokanine A was accomplished by asymmetric deprotonation of N-Boc pyrrolidine, followed by the reaction of the in situ generated enantioenriched ...

Formation of enehydrazine intermediates through coupling of phenylhydrazines with vinyl halides: entry into the Fischer indole synthesis.

Angew. Chem. Int. Ed. Engl. 52(4) , 1266-9, (2013)


More Articles


Related Compounds

  • Bromoethene
  • 1-bromoethene-2,2-d2
  • (Z)-2-ethoxy-1-bromoethene
  • 2-(trimethylsilyl)bromoethene
  • 2-(trimethylsilyl)bromoethene
  • 1-bromoethene-1-diethylsulfonamide
  • 2-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)-N-(p-tolyl)acetamide
  • 2-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)-N-(2-(trifluoromethyl)benzyl)acetamide
  • N-(2-chloro-4-fluorobenzyl)-2-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)acetamide
  • N-(4-chlorophenyl)-3-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)propanamide
  • 3-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)-N-phenylpropanamide
  • N-(3-chloro-4-methoxyphenyl)-3-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)propanamide
  • 3-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)-N-(3-(methylthio)phenyl)propanamide
  • N-[(2H-1,3-benzodioxol-5-yl)methyl]-3-{8-methyl-4-oxo-3H,4H,5H-pyrimido[5,4-b]indol-3-yl}propanamide
  • N-(4-ethylbenzyl)-3-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)propanamide
  • 3-{8-methyl-4-oxo-3H,4H,5H-pyrimido[5,4-b]indol-3-yl}-N-[(pyridin-4-yl)methyl]propanamide
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