2-Hydroxyisobutyric acid

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Names

[ CAS No. ]:
594-61-6

[ Name ]:
2-Hydroxyisobutyric acid

[Synonym ]:
2-hydroxy-2-methyl-propanoic acid
2-MethyllaCLic Acid
α-Hydroxy-α-methylpropanoic acid
α-hydroxyisobutyric acid
Hydroxyisobutyricacid
Lactic acid,2-methyl
Hydroxydimethylacetic acid
a-Hydroxyisobutyric acid
EINECS 209-848-8
RARECHEM AL BO 0199
2-hydroxy-2-methyl-propionic acid
a-Hydroxyisobutanoic acid
Propanoic acid, 2-hydroxy-2-methyl-
Lactic acid, 2-methyl- (8CI)
2-METHYLLACTIC ACID
2-Hydroxyisobutyric
2-Hydroxy-2-methylpropanoic acid
lactic acid, 2-methyl-
MFCD00004459
2-methyl-2-hydroxypropanoic acid
METHYL LACTIC ACID
2,2-DIMETHYLGLYCOLIC ACID
a-Hydroxy-a-methylpropanoic acid
2-Hydroxyisobutyric acid
α-Hydroxyisobutanoic acid
2-Hydroxy-2-methylpropionic acid

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
212.0±0.0 °C at 760 mmHg

[ Melting Point ]:
76-80 °C(lit.)

[ Molecular Formula ]:
C₄H₈O₃

[ Molecular Weight ]:
104.104

[ Flash Point ]:
104.9±16.3 °C

[ Exact Mass ]:
104.047340

[ PSA ]:
57.53000

[ LogP ]:
-0.35

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.457

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R41

[ Safety Phrases ]:
S26-S39-S25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Citraconic acid
Itaconic acid
Mesaconic acid
2-isopropylidene-1,3-benzodithiole
Ethyl α-hydroxyisobutyrate
Isobutylene
ammonium 2-hydroxyisobutyrate
2-Methyl-1,2-propanediol
Acetone cyanohydrin
2-methyl-2-(sulphooxy)propionamide

DownStream

2-(2,2-dimethylpropanoyloxy)-2-methylpropanoic acid
octyl 2-hydroxy-2-methylpropanoate
octyl benzoate
Phenoxyisobutyric acid
1-Chloro-2-methyl-1-oxopropan-2-yl acetate
prop-2-enyl 2-hydroxy-2-methylpropanoate
Benzyl 2-Hydroxy-2-Methylpropionate
Methacrylic acid
Propanoic acid,2-(acetyloxy)-2-methyl-
Acetone

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Thermophilic Coenzyme B12-Dependent Acyl Coenzyme A (CoA) Mutase from Kyrpidia tusciae DSM 2912 Preferentially Catalyzes Isomerization of (R)-3-Hydroxybutyryl-CoA and 2-Hydroxyisobutyryl-CoA.

Appl. Environ. Microbiol. 81 , 4564-72, (2015)

The recent discovery of a coenzyme B12-dependent acyl-coenzyme A (acyl-CoA) mutase isomerizing 3-hydroxybutyryl- and 2-hydroxyisobutyryl-CoA in the mesophilic bacterium Aquincola tertiaricarbonis L108...

Capillary electrophoresis of small ions using complex formation and indirect detection.

Electrophoresis 30 Suppl 1 , S34-9, (2009)

The journal Electrophoresis was launched in about the same time as modern CE. Today, Electrophoresis is one of the leading journals in the field of analytical separations. With over 23% of all papers ...

Solid-state and solution-state coordination chemistry of lanthanide(III) complexes with α-hydroxyisobutyric acid.

Inorg. Chem. 51(24) , 13254-63, (2012)

Despite the wide range of applications of α-hydroxyisobutyric acid (HIBA) in biochemical processes, pharmaceutical formulations, and group and elemental separations of lanthanides and actinides, the s...