8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol

Names

[ CAS No. ]:
59468-85-8

[ Name ]:
8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol

[Synonym ]:
8-Chloro-6-(2-fluorophenyl)-4-hydroxy-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
8-Chloro-6-(2-fluorophenyl)-4-hydroxy-4H-imidazo[1,5a][1,4]bezodiazepine
4-OH-Mdz
4-hydroxy-MDZ
8-chloro-(2-fluoro-phenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-4-ol
4-Hydroxy Midazolam

Chemical & Physical Properties

[ Density]:
1.44g/cm3

[ Boiling Point ]:
550.6ºC at 760 mmHg

[ Melting Point ]:
186-187ºC

[ Molecular Formula ]:
C18H13ClFN3O

[ Molecular Weight ]:
341.76700

[ Flash Point ]:
286.8ºC

[ Exact Mass ]:
341.07300

[ PSA ]:
50.41000

[ LogP ]:
3.25070

[ Index of Refraction ]:
1.688

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Midazolam

DownStream

  • 4-Hydroxymidazolam beta-D-Glucuronide

Articles

A comparison of the metabolism of midazolam in C57BL/6J and hepatic reductase null (HRN) mice.

Biochem. Pharmacol. 92(4) , 701-11, (2014)

The hepatic cytochrome P450 reductase null (HRN) mouse, which has no functional hepatic Cyp P450s, may represent a useful model for examining extra-hepatic P450-related oxidative metabolism. Here the ...

Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity.

J. Chromatogr. A. 1374 , 122-33, (2014)

The present study investigated the practical use of modern ultra-high performance liquid chromatography (UHPLC) separation techniques for drug metabolite profiling, aiming to develop a widely applicab...

Species differences and substrate specificity of CYP3A heteroactivation by efavirenz.

Xenobiotica 45(4) , 345-52, (2015)

1. The purpose of this study was to clarify species differences in the heteroactivation of CYP3A substrates by efavirenz, which is known from clinical studies to activate midazolam 1'-hydroxylation, a...


More Articles

Related Compounds

  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • (3S)-3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetamido]heptanoic acid
  • 3-[2-cyclopropyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetamido]-3-(thiophen-2-yl)propanoic acid
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine