2-Amino-5-bromopyrazine

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Names

[ CAS No. ]:
59489-71-3

[ Name ]:
2-Amino-5-bromopyrazine

[Synonym ]:
5-bromopyrazin-2-amine
MFCD00235015
2-Pyrazinamine, 5-bromo-
5-Bromo-2-pyrazinamine
5-Brompyrazin-2-amin
2-Amino-5-bromopyrazine

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
274.2±35.0 °C at 760 mmHg

[ Melting Point ]:
113-117 °C(lit.)

[ Molecular Formula ]:
C4H4BrN3

[ Molecular Weight ]:
174.00

[ Flash Point ]:
119.7±25.9 °C

[ Exact Mass ]:
172.958847

[ PSA ]:
51.80000

[ LogP ]:
1.55

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.649

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H317-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22;R36/37/38;R44

[ Safety Phrases ]:
S26-S37/39-S45-S36/37/39-S22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Aminopyrazine
  • 2-Amino-3,5-dibromopyrazine
  • 3-Amino-6-bromopyrazine-2-carboxylic acid

DownStream

  • 5-Amino-2-pyrazinecarboxamide
  • 5-Aminopyrazine-2-carboxylic acid
  • 5-Bromopyrazin-2-ol
  • 6-Bromoimidazo[1,2-a]pyrazine
  • Pyrazinamine,5-(methylthio)-(9Cl)
  • 2,5-Dibromopyrazine
  • 2-Bromo-5-iodopyrazine
  • 5-Methoxypyrazin-2-amin
  • N-(5-bromopyrazin-2-yl)-2,6-difluorobenzamide
  • 5-Aminopyrazine-2-carbonitrile

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Palladium-catalyzed cross-coupling reactions of pyridylboronic acids with heteroaryl halides bearing a primary amine group: synthesis of highly substituted bipyridines and pyrazinopyridines.

J. Org. Chem. 70 , 388, (2005)

A range of halogenated aromatics and heteroaromatics bearing a primary amine group are shown to be suitable substrates for Suzuki cross-coupling reactions with arylboronic acids and pyridylboronic aci...


More Articles

Related Compounds

  • 2-Amino-5-bromopyrazine-3-carboxylic Acid
  • 2-Amino-3-benzyloxy-5-bromopyrazine
  • 2-amino-5-methoxy-4-phenylmethoxybenzamide
  • 2-Amino-5,7-dimethylisoxazolo[2,3-a]pyrimidinium Chloride
  • 2-amino-5-methyl-phenylphosphonic acid diethylester
  • 2-Amino-5-nitronicotinic acid
  • N-(3-(4-fluorophenyl)-2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)-4-nitrobenzamide
  • N-(3-(4-fluorophenyl)-2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)-2,4-dimethoxybenzamide
  • N-(2-(benzo[d][1,3]dioxol-5-yloxy)ethyl)-2-methoxy-4-methylbenzenesulfonamide
  • N-(3-(4-fluorophenyl)-2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)-3-(4-methoxyphenyl)propanamide
  • 2,4-dimethyl-N-(2-methyl-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)thiazole-5-carboxamide
  • N-(2-methyl-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)pivalamide
  • 1-(3-Chloro-2-methylphenyl)-3-(3-(4-fluorophenyl)-2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)urea
  • N-(2-methyl-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)butanamide
  • 2-methyl-N-(2-methyl-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)benzamide
  • N-(3-(4-chlorophenyl)-2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)-4-(N,N-dimethylsulfamoyl)benzamide
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