Benzeneethanol, b-amino-a-phenyl-, hydrochloride (1:1)

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Names

[ Name ]:
Benzeneethanol, b-amino-a-phenyl-, hydrochloride (1:1)

[Synonym ]:
ISOQUINOLINE,1,2,3,4-TETRAHYDRO-2-AMINO
2-AMINO-1,2,3,4-TETRAHYDROISOQUINOLINE
2-amino-3,4-dihydro-1H-isoquinoline
N-Amino-1,2,3,4-tetrahydroisoquinoline
1,2,3,4-tetrahydro-2-amino-isoquinoline
3,4-dihydro-1H-isoquinolin-2-ylamine
1,2-diphenyl-2-aminoethanol hydrochloride
2-Amino-1,2,4-oxadiazol

Chemical & Physical Properties

[ Boiling Point ]:
374.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₆ClNO

[ Molecular Weight ]:
249.73600

[ Flash Point ]:
180.2ºC

[ Exact Mass ]:
249.09200

[ PSA ]:
46.25000

[ LogP ]:
3.92230

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DN3160000

CHEMICAL NAME :: Benzyl alcohol, alpha-(alpha-aminobenzyl)-, hydrochloride

CAS REGISTRY NUMBER :: 5959-42-2

LAST UPDATED :: 199206

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C14-H15-N-O.Cl-H

MOLECULAR WEIGHT :: 249.76

WISWESSER LINE NOTATION :: ZYR&YQR &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SAPHAO Skandinavisches Archiv fuer Physiologie. (Stockholm, Sweden) V.1-83, 1899-1940. For publisher information, see APSCAX. Volume(issue)/page/year: 79,258,1938

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 336 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 39,354,1950

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Vascular - BP elevation not characterized in autonomic section

REFERENCE :: JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 52,3317,1930

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Vascular - BP elevation not characterized in autonomic section

REFERENCE :: JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 52,3317,1930

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(1E)-1,2-Diphenylethane-1,2-dione 1-oxime
(Z)-2-Hydroxyimino-1,2-diphenylethanone
(E)-2-hydroxy-1,2-diphenylethan-1-one oxime

DownStream

Related Compounds

2-Chloro-5-[3-(methoxycarbonyl)phenyl]pyrimidine
4-Hydroxy-6-methyl-3-(3-methylbut-3-en-2-yl)pyran-2-one
1-Tert-butyl-3,5-bis(chloromethyl)benzene
N,3,3-trimethylcyclobutan-1-amine
3-Methyl-5-pentyl-2-furanpropanoic acid
3 Methyl-5-heptyl-2-furanpentanoic acid
3-(3-Acetamido-4-methoxyphenyl)propanoic acid
1-(3-aminopropyl)-6-(5-fluoro-2-methoxyphenyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
2,4-Dimethoxy-3-fluorophenylacetic acid
3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonyl fluoride

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