(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-2-[2-(phenoxymethyl)-1,3-dioxolan-2-yl]ethenyl]cyclopentyl]hept-5-enoic acid

Names

[ Name ]:
(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-2-[2-(phenoxymethyl)-1,3-dioxolan-2-yl]ethenyl]cyclopentyl]hept-5-enoic acid

[Synonym ]:
(5Z)-7-[(1R,2R,3R)-3,5-Dihydroxy-2-{(E)-2-[2-(phenoxymethyl)-1,3-dioxolan-2-yl]vinyl}cyclopentyl]-5-heptenoic acid
15-Deoxy-15,15-ethylenedioxy-16-phenoxy-17,18,19,20-tetranorprostaglandinF2a
Etiprostone [INN-French]
(5Z,13E)-(8R,9S,11R,12R)-9,11-Dihydroxy-15,15-ethylenedioxy-16-phenoxy-17,18,19,20-tetranorprostadienoic Acid
Etiprostonum [INN-Latin]
Etiprostone
Etiprostonum
Etiproston
5-Heptenoic acid, 7-[(1R,2R,3R)-3,5-dihydroxy-2-[(E)-2-[2-(phenoxymethyl)-1,3-dioxolan-2-yl]ethenyl]cyclopentyl]-, (5Z)-
(5Z)-7-[(1R,2R,3R)-3,5-Dihydroxy-2-{(E)-2-[2-(phenoxymethyl)-1,3-dioxolan-2-yl]vinyl}cyclopentyl]hept-5-enoic acid
(5Z,13E)-(8R,9S,11R,12R)-9,11-dihydroxy-15,15-ethylenedioxy-16-phenoxy-17,18,19,20-tetranor-prostadienoic acid
Etiproston (INN)
(5Z)-7-[(1R,2R,3R)-3,5-dihydroxy-2-{(E)-2-[2-(phenoxymethyl)-1,3-dioxolan-2-yl]ethenyl}cyclopentyl]hept-5-enoic acid
[1R-(1a(Z),2b(E),3a,5a)]-7-[3,5-Dihydroxy-2-[2-[2-(phenoxymethyl)-1,3-dioxolan-2-yl]ethenyl]cyclopentyl]-5-heptenoic Acid

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
598.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₃₂O₇

[ Molecular Weight ]:
432.507

[ Flash Point ]:
200.2±23.6 °C

[ Exact Mass ]:
432.214813

[ PSA ]:
105.45000

[ LogP ]:
1.66

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.633

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MJ9671000

CHEMICAL NAME :: 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(2-(2-(phenoxymethyl)-1,3-dioxolan -2-yl)ethenyl) cyclopentyl)-, (1R-(1-alpha(Z),2-beta(E),3-alpha,5-alpha))-

CAS REGISTRY NUMBER :: 59619-81-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C24-H32-O7

MOLECULAR WEIGHT :: 432.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 600 ug/kg

SEX/DURATION :: female 4-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,443,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 25 ug/kg

SEX/DURATION :: female 29 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - physical

REFERENCE :: ANIPA8 Animal Production. (Scotish Academic Press Ltd., 33 Montgomery Street, Edinburgh EH7 5JX, UK) V.1- 1959- Volume(issue)/page/year: 49,129,1989

Related Compounds

4,4-Difluorobut-3-en-1-ol
N1-(2-(dimethylamino)ethyl)-N2-(2-methyl-5-nitrophenyl)oxalamide
4-(3-phenylpyrazol-1-yl)-1H-pyrrolo[2,3-b]pyridine
N1-(2-hydroxyethyl)-N2-(2-methyl-5-nitrophenyl)oxalamide
N1-(3-hydroxypropyl)-N2-(2-methyl-5-nitrophenyl)oxalamide
N1-(2-methyl-5-nitrophenyl)-N2-(2-morpholinoethyl)oxalamide
N1-(2-methoxyphenethyl)-N2-(2-methyl-5-nitrophenyl)oxalamide
2-[4-(4-fluorophenyl)piperazin-1-yl]-N-(2-methyl-5-nitrophenyl)-2-oxoacetamide
N1-(benzo[d][1,3]dioxol-5-ylmethyl)-N2-(2-methyl-5-nitrophenyl)oxalamide
N1-(2-methyl-5-nitrophenyl)-N2-(thiophen-2-ylmethyl)oxalamide

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