Bufuralol

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Names

[ CAS No. ]:
59652-29-8

[ Name ]:
Bufuralol

[Synonym ]:
a-[[(1,1-Dimethylethyl)-amino]methyl]-7-ethyl-2-benzofuranmethanol
Bufuralol HCl
AngiumHCl
2-tert-butylamino-1-(7-ethyl-2-benzofuranyl)-ethanohydrochloride
2-tert-butylamino-1-(7-ethyl-2-benzofuranyl)ethanolhydrochloride
BUFURALOL,HYDROCHLORIDE
bufurololhydrochloride
ANGIUM
ro3-4787

Chemical & Physical Properties

[ Melting Point ]:
143-146ºC

[ Molecular Formula ]:
C16H24ClNO2

[ Molecular Weight ]:
297.82000

[ Exact Mass ]:
297.15000

[ PSA ]:
45.40000

[ LogP ]:
4.60960

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KK0207500
CHEMICAL NAME :
Ethanol, 2-tert-butylamino-1-(7-ethyl-2-benzofuranyl)-, hydrochloride
CAS REGISTRY NUMBER :
59652-29-8
LAST UPDATED :
199706
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C16-H23-N-O2.Cl-H
MOLECULAR WEIGHT :
297.86
WISWESSER LINE NOTATION :
T56 BOJ CYQ1MX1&1&1 I2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1410,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1410,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
177 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1410,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
88 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1410,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
29700 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1410,1977

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22


Related Compounds

  • Bufuralol
  • Bufuralol
  • dl-Bufuralol
  • (+)-Bufuralol
  • 1'-Hydroxy Bufuralol
  • Bufuralol hydrochloride
  • 2-(2-Cyano-5-(difluoromethyl)-3-((trifluoromethyl)thio)phenyl)acetic acid
  • tert-Butyl N-(4-cyclopropyl-4-oxobutan-2-yl)carbamate
  • [5-(4-Fluoro-3-methylphenyl)-1H-pyrazol-3-yl][4-(2-methoxyphenyl)-1-piperazinyl]methanone
  • 1-(6-Amino-2-chloropyridin-3-yl)-2-bromoethan-1-one
  • 4-(Difluoromethyl)-6-iodo-5-methylpyridine-2-sulfonamide
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2,4-Dibromophenazin-1-amine
  • 1-(4-Bromo-2-(trifluoromethyl)benzyl)piperazine
  • 3-(Bromomethyl)-2-(difluoromethyl)-4-nitropyridine