Dimethyl morpholinophosphoramidate.

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Names

[ CAS No. ]:
597-25-1

[ Name ]:
Dimethyl morpholinophosphoramidate.

[Synonym ]:
Dimethyl 4-morpholinylphosphonate
HC 1717
Morpholino-phosphonsaeure-dimethylester
N,N-oxydiethylene-O,O-dimethylphosphoramidate
Dimethylmorpholinophosphonate
morpholin-4-yl-phosphonic acid dimethyl ester
Orthophosphorsaeure-dimethylester-morpholinid
DIMETHYL MORPHOLINOPHOSPHORAMIDATE
Dimethyl morpholino phosphoroamidite
dimethyl morpholin-4-ylphosphonate

Chemical & Physical Properties

[ Density]:
1.21g/cm3

[ Boiling Point ]:
246.8ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₁₄NO₄P

[ Molecular Weight ]:
195.15300

[ Flash Point ]:
103.1ºC

[ Exact Mass ]:
195.06600

[ PSA ]:
57.81000

[ LogP ]:
0.65740

[ Index of Refraction ]:
1.454

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ9660000

CHEMICAL NAME :: Phosphonic acid, morpholino-, dimethyl ester

CAS REGISTRY NUMBER :: 597-25-1

BEILSTEIN REFERENCE NO. :: 0141995

LAST UPDATED :: 199710

DATA ITEMS CITED :: 22

MOLECULAR FORMULA :: C6-H14-N-O4-P

MOLECULAR WEIGHT :: 195.18

WISWESSER LINE NOTATION :: T6N DOTJ APO&O1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5910 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 347 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 35 gm/kg/14D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 52 gm/kg/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 gm/kg/14D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 26 gm/kg/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 309 gm/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia

TYPE OF TEST :: Specific locus test

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 3 gm/L

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-298,1986

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-(Morpholinothio)benzothiazole
Trimethyl phosphite
Methyl phosphite, (MeO)2(HO)P
morpholine
Dimethyl chlorophosphate
Methanol
4-diphenoxyphosphorylmorpholine

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

dimethyl-bis(2-methylpropyl)azanium,iodide
[dimethyl(phenyl)-λ5-arsanyl] thiohypobromite
[dimethyl(phenyl)-λ5-arsanyl] thiohypochlorite
dimethyl glutarate
dimethyl cyclopentane-1,1-dicarboxylate
Dimethyl malate
2-Amino-3-{pyrido[2,3-b]pyrazin-7-yl}propanoic acid
3-(1-methyl-1H-pyrazol-4-yl)but-2-enoic acid
N,N-diallyl-2-fluoropyridin-4-amine
2-Chloro-4-(4,4-difluoropiperidin-1-yl)pyridine
2-Methyl-3-(4-methylcyclohexyl)prop-2-en-1-ol
(2Z)-3-(3-Chlorophenyl)-2-fluoroprop-2-enoic acid
4-(1,4-diazepan-1-yl)-N-methylpyrimidin-2-amine
(4-(4-Methoxypiperidin-1-yl)pyrimidin-2-yl)methanamine
5-Bromo-2-chloro-6-fluoro-1H-1,3-benzimidazole
2,3-Dichloroprop-2-ene-1-sulfonyl chloride

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