N-Ethyl-2,3-dioxopiperazine

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Names

[ CAS No. ]:
59702-31-7

[ Name ]:
N-Ethyl-2,3-dioxopiperazine

[Synonym ]:
1-ethylpiperazine-2,3-dione
MFCD00051825
EINECS 261-866-5
1-Ethyl-2,3-piperazinedione
2,3-Piperazinedione, 1-ethyl-
N-Ethyl-2,3-dioxopiperazine
1-Ethyl-2,3-dioxopiperazine
4-ETHYL-2,3 DIOXO PIPERAZINE
Piperacillin Impurity 5

Chemical & Physical Properties

[ Density]:
0.64

[ Boiling Point ]:
346ºC

[ Melting Point ]:
121-126 ºC

[ Molecular Formula ]:
C6H10N2O2

[ Molecular Weight ]:
142.156

[ Exact Mass ]:
142.074234

[ PSA ]:
49.41000

[ LogP ]:
-1.56

[ Index of Refraction ]:
1.475

[ Water Solubility ]:
2000 g/L

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL6380250
CHEMICAL NAME :
2,3-Piperazinedione, 1-ethyl-
CAS REGISTRY NUMBER :
59702-31-7
BEILSTEIN REFERENCE NO. :
0879076
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C6-H10-N2-O2
MOLECULAR WEIGHT :
142.18
WISWESSER LINE NOTATION :
T6MVVNTJ D2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4830 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 97,987,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6932 No. of Facilities: 4 (estimated) No. of Industries: 1 No. of Occupations: 16 No. of Employees: 1391 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
3

[ RTECS ]:
TL6380250

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 6-[(+/-)-α-amino-α-(2-aminothiazol-4-yl)acetamido]penicillanic acid
  • 4-ethyl-2,3-dioxopiperazin-1-carbonylchlorid

DownStream

  • 4-ethyl-2,3-dioxopiperazin-1-carbonylchlorid
  • 2-(4-ethyl-2,3-dioxo-piperazin-1-yl)acetic acid

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • N-ethyl-2,3,3-trimethylbutan-2-amine,hydrochloride
  • N-ethyl-2,3-dimethylbicyclo[2.2.1]hept-5-ene-3-carboxamide
  • N-ethyl-2-(3-methoxyphenoxy)ethanamine
  • N-ethyl-2,3,4,6,N-pentanitro-aniline
  • N-Ethyl-2,3-difluorobenzylamine
  • N-Ethyl-2,3-difluoro-6-nitroaniline
  • 3-benzyl-6-{[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}-3H,6H,7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
  • 6-{[3-(2H-1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-5-yl]methyl}-3-[(2-methylphenyl)methyl]-3H,6H,7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
  • 3-[(3-chlorophenyl)methyl]-6-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]-3H,6H,7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
  • 3-[(3-chlorophenyl)methyl]-6-{[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}-3H,6H,7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
  • 3-(3-chlorobenzyl)-6-{[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}-3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
  • 6-{[3-(2H-1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-5-yl]methyl}-3-[(3-chlorophenyl)methyl]-3H,6H,7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
  • 3-(3-chlorobenzyl)-6-{[3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}-3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
  • 3-(3-chlorobenzyl)-6-({3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}methyl)-3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
  • 3-[(3-chlorophenyl)methyl]-6-({3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}methyl)-3H,6H,7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
  • 3-[(3-chlorophenyl)methyl]-6-{[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]methyl}-3H,6H,7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
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