Lorcainide
Names
[ CAS No. ]:
59729-31-6
[ Name ]:
Lorcainide
[Synonym ]:
Lorcainidum [INN-Latin]
Benzeneacetamide,N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]
N-(4-chloro-phenyl)-N-(1-isopropyl-piperidin-4-yl)-2-phenyl-acetamide
LORCAINIDE
N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]benzeneacetamide
Lorcainida [INN-Spanish]
4'-Chloro-N-(1-isopropyl-4-piperidyl)-2-phenylacetanilide
Lorcainide [INN:BAN]
lorcainid
Chemical & Physical Properties
[ Density]:
1.161g/cm3
[ Boiling Point ]:
503ºC at 760 mmHg
[ Molecular Formula ]:
C22H27ClN2O
[ Molecular Weight ]:
370.91600
[ Flash Point ]:
258ºC
[ Exact Mass ]:
370.18100
[ PSA ]:
23.55000
[ LogP ]:
4.72640
[ Index of Refraction ]:
1.594
[ Storage condition ]:
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CY1483600
- CHEMICAL NAME :
- Benzeneacetamide, N-(4-chlorophenyl)-N-(1-(1-methylethyl)-4-piperidinyl )-
- CAS REGISTRY NUMBER :
- 59729-31-6
- BEILSTEIN REFERENCE NO. :
- 0497568
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C22-H27-Cl-N2-O
- MOLECULAR WEIGHT :
- 370.96
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - coma Cardiac - pulse rate
- REFERENCE :
- JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 33,157,1995
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 395 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RMISDU International Congress and Symposium Series - Royal Society of Medicine Services Limited. (Royal Society of Medicine Services Ltd., 7E. 60th St., New York, NY 10022) No.1- 1978- Volume(issue)/page/year: 49,23,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18600 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RMISDU International Congress and Symposium Series - Royal Society of Medicine Services Limited. (Royal Society of Medicine Services Ltd., 7E. 60th St., New York, NY 10022) No.1- 1978- Volume(issue)/page/year: 49,23,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 483 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RMISDU International Congress and Symposium Series - Royal Society of Medicine Services Limited. (Royal Society of Medicine Services Ltd., 7E. 60th St., New York, NY 10022) No.1- 1978- Volume(issue)/page/year: 49,23,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 18800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RMISDU International Congress and Symposium Series - Royal Society of Medicine Services Limited. (Royal Society of Medicine Services Ltd., 7E. 60th St., New York, NY 10022) No.1- 1978- Volume(issue)/page/year: 49,23,1981
Safety Information
[ Hazard Codes ]:
Xn
[ Safety Phrases ]:
26-36/37