2-Oxo-1-Pyrrolidineacetic Acid Methyl Ester

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Names

[ CAS No. ]:
59776-88-4

[ Name ]:
2-Oxo-1-Pyrrolidineacetic Acid Methyl Ester

[Synonym ]:
MFCD00003198
methyl 2-(2-oxopyrrolidin-1-yl)acetate
EINECS 261-926-0
2-Oxo-1-Pyrrolidineacetic Acid Methyl Ester
Piracetam Impurity 2

Chemical & Physical Properties

[ Density]:
1.131 g/mL at 25 °C(lit.)

[ Boiling Point ]:
291.3ºC at 760 mmHg

[ Molecular Formula ]:
C7H11NO3

[ Molecular Weight ]:
157.16700

[ Flash Point ]:
130.0±22.6 ºC

[ Exact Mass ]:
157.07400

[ PSA ]:
46.61000

[ Index of Refraction ]:
n20/D 1.472(lit.)

[ Water Solubility ]:
Soluble (53 g/L) (25 ºC)

MSDS

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Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933790090

Synthetic Route

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Precursor & DownStream

Precursor

  • 2-Pyrrolidinone
  • Methyl bromoacetate
  • METHYL DIAZOACETATE
  • 1-trimethylsilyl-2-pyrrolidinone

DownStream

  • Piracetam
  • (2-Oxopyrrolidin-1-yl)acetic
  • 1-(2-Hydroxyethyl)-2-pyrrolidinone
  • (2-Oxo-1-pyrrolidinyl)acetaldehyde
  • Piracetam hydrazine

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Articles

Amnesia-reversal activity of a series of N-[(disubstituted-amino)alkyl] -2-oxo-1-pyrrolidineacetamides, including pramiracetam.

J. Med. Chem. 27(5) , 684-91, (1984)

A series of N-[(dialkylamino)alkyl]-2-oxo-1- pyrrolidineacetamides was synthesized. The title compounds reversed electroconvulsive shock (ECS) induced amnesia in mice when administered subsequent to t...


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  • 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid methyl ester
  • 2-oxo-1-(6-trimethylsilanylmethyl-hepta-4,6-dienyl)-cyclopentanecarboxylic acid methyl ester
  • 2-oxo-1-(2-oxo-4-phenyl-oxazolidin-3-yl)-bicyclo[3.1.0]hexane-6-carboxylic acid methyl ester