Chlormethiazole hydrochloride

[ Melting Point ]:
136 °C

[ Molecular Formula ]:
C₆H₉Cl₂NS

[ Molecular Weight ]:
297.52200

[ Exact Mass ]:
295.95200

[ PSA ]:
57.14000

[ LogP ]:
2.23800

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[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H317-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-41-43

[ Safety Phrases ]:
26-36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2934100090

Click to get detail synthetic route

Precursor

DownStream

[ HS Code ]: 2934100090

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Identification of human cytochrome P450 isozymes involved in the metabolism of naftopidil enantiomers in vitro.

J. Pharm. Pharmacol. 66(11) , 1534-51, (2014)

Naftopidil (NAF) is a chiral compound with two enantiomers (R(+)-NAF and S(-)-NAF) and is used as a racemic mixture in clinical practice. This study aims to investigate the metabolism of NAF enantiome...

Chlormethiazole: effectiveness against toxic effects of cocaine in mice.

J. Pharmacol. Exp. Ther. 295 , 153-161, (2000)

Chlormethiazole positively modulates the gamma-aminobutyric acid (GABA)(A) receptor complex and is primarily used to treat certain life-threatening neurological events (e.g., refractory seizures and e...

Diazepam and chlormethiazole attenuate the development of hyperthermia in an animal model of the serotonin syndrome.

Neurochem. Int. 43 , 155-164, (2003)

The serotonin (5-HT) syndrome is the most serious toxic interaction of antidepressants, but no pharmacotherapy has yet been established. In the present study, we created an animal model of the 5-HT sy...

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