TETRAHYDROPALMATINE HYDROCHLORIDE

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Names

[ Name ]:
TETRAHYDROPALMATINE HYDROCHLORIDE

[Synonym ]:
Tetrahydropalmatine,HCl
corydalis B
rac-2,3,9,10-tetramethoxy-berbine,hydrochloride
2,3,9,10-Tetramethoxyberbine hydrochloride
Tetrahydropalmatini,Sulfas
rac-2,3,9,10-Tetramethoxy-berbin,Hydrochlorid
MFCD00156231
DI-TETRAHYDROPALMATINE
tetrahydro-,hydrochloride,(+-)-palmatin

Chemical & Physical Properties

[ Boiling Point ]:
482.9ºC at 760 mmHg

[ Melting Point ]:
250-252ºC

[ Molecular Formula ]:
C₂₁H₂₆ClNO₄

[ Molecular Weight ]:
391.888

[ Flash Point ]:
138.7ºC

[ Exact Mass ]:
391.155029

[ PSA ]:
40.16000

[ LogP ]:
4.11640

[ Storage condition ]:
2-8C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DR9840000

CHEMICAL NAME :: Berbine, 2,3,9,10-tetramethoxy-, hydrochloride, (+-)-

CAS REGISTRY NUMBER :: 6024-85-7

LAST UPDATED :: 199012

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H25-N-O4.Cl-H

MOLECULAR WEIGHT :: 391.93

WISWESSER LINE NOTATION :: T D6 B666 KN&TT&J GO1 HO1 PO1 QO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 17,30,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 121500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 5,163,1946