HARMALINE HYDROCHLORIDE DIHYDRATE

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Names

[ CAS No. ]:
6027-98-1

[ Name ]:
HARMALINE HYDROCHLORIDE DIHYDRATE

[Synonym ]:
Harmaline hydrochloride
EINECS 253-734-0
3,4-DIHYDRO-7-METHOXY-1-METHYL-9H-PYRIDO[3,4-B]-INDOLE HYDROCHLORIDE DIHYDRATE
HARMALOL METHYL ETHER HYDROCHLORIDE DIHYDRATE
4,9-dihydro-7-methoxy-1-methyl-3H-Pyrido[3,4-b]indole hydrochloride hydrate
HARMALINE HCL DIHYDRATE(RG)
MFCD00150052

Chemical & Physical Properties

[ Boiling Point ]:
426.4ºC at 760 mmHg

[ Melting Point ]:
232-240 °C

[ Molecular Formula ]:
C13H19ClN2O3

[ Molecular Weight ]:
286.75500

[ Flash Point ]:
211.7ºC

[ Exact Mass ]:
286.10800

[ PSA ]:
55.84000

[ LogP ]:
2.65060

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MG8750000
CHEMICAL NAME :
Harmaline, hydrochloride, dihydrate
CAS REGISTRY NUMBER :
6027-98-1
LAST UPDATED :
199106
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C13-H14-N2-O.Cl-H.2H2-O
MOLECULAR WEIGHT :
286.79

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TRSEAO Transactions of the Royal Society of Edinburgh. (Edinburgh, Scotland) V.1-70, 1783-1979. Volume(issue)/page/year: 47,245,1909
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TRSEAO Transactions of the Royal Society of Edinburgh. (Edinburgh, Scotland) V.1-70, 1783-1979. Volume(issue)/page/year: 47,245,1909
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TRSEAO Transactions of the Royal Society of Edinburgh. (Edinburgh, Scotland) V.1-70, 1783-1979. Volume(issue)/page/year: 47,245,1909
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TRSEAO Transactions of the Royal Society of Edinburgh. (Edinburgh, Scotland) V.1-70, 1783-1979. Volume(issue)/page/year: 47,245,1909
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TRSEAO Transactions of the Royal Society of Edinburgh. (Edinburgh, Scotland) V.1-70, 1783-1979. Volume(issue)/page/year: 47,245,1909

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn,Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
1544

[ WGK Germany ]:
3

[ RTECS ]:
MG8750000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

  • 1H-Pyrido[3,4-b]indole,2,3,4,9-tetrahydro-7-methoxy-1-methyl- (9CI)

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Apomorphine enhances harmaline-induced tremor in rats.

Pharmacol. Rep. 67 , 435-41, (2015)

Harmaline-induced tremor is a well-known model of essential tremor in humans. The aim of the present study was to examine the influence of apomorphine, a non-selective dopamine receptor agonist, on th...


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