Triphenylphosphine

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Names

[ CAS No. ]:
603-35-0

[ Name ]:
Triphenylphosphine

[Synonym ]:
PP-360
Triphenyphosphine
EINECS 210-036-0
tetrakistriphenylphosphine
Trihenylphosphine
triphenyl-phosphin
Triphenylphosphine
4-16-00-00951 (Beilstein Handbook Reference)
PPh3
Triphenyl phosphine
Triphenyl
bistriphenylphosphine
Ph3P
MFCD00003043
diphenylenephenylphosphine
Trifenylfosfin
Triphenylphosphide
triphenylphosphane
Phosphine, triphenyl-

Chemical & Physical Properties

[ Density]:
1.132

[ Boiling Point ]:
360.0±11.0 °C at 760 mmHg

[ Melting Point ]:
79-81 °C(lit.)

[ Molecular Formula ]:
C₁₈H₁₅P

[ Molecular Weight ]:
262.285

[ Flash Point ]:
181.7±0.0 °C

[ Exact Mass ]:
262.091125

[ PSA ]:
13.59000

[ LogP ]:
5.69

[ Vapour density ]:
9 (vs air)

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.5918 (20ºC)

[ Stability ]:
Stable. Incompatible with oxidizing agents, acids.

[ Water Solubility ]:
Insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ3500000

CHEMICAL NAME :: Phosphine, triphenyl-

CAS REGISTRY NUMBER :: 603-35-0

BEILSTEIN REFERENCE NO. :: 0610776

LAST UPDATED :: 199710

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C18-H15-P

MOLECULAR WEIGHT :: 262.30

WISWESSER LINE NOTATION :: RPR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1114,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1114,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0384-0014

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1135 ppm/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: AIHAM* Annual Meeting of American Industrial Hygiene Association. (Akron, OH) For publisher information, see AIHAAP. Volume(issue)/page/year: -,-,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0384-0014

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0384-0014

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0384-0014

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570648

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,313,1974

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 9 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0384-0014 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 950 mg/kg/14D-I

TOXIC EFFECTS :: Spinal Cord - other degenerative changes Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570648

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 525 mg/kg/21D-I

TOXIC EFFECTS :: Spinal Cord - demyelination Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570648

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 94500 ug/m3/6H/4W-I

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570648 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4096 No. of Facilities: 268 (estimated) No. of Industries: 13 No. of Occupations: 18 No. of Employees: 14258 (estimated) No. of Female Employees: 1373 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H317-H373

[ Precautionary Statements ]:
P280

[ Target Organs ]:
Nervous system

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R43;R53

[ Safety Phrases ]:
S36/37-S60-S61-S36/37/39-S26

[ RIDADR ]:
3077

[ WGK Germany ]:
2

[ RTECS ]:
SZ3500000

[ Hazard Class ]:
6.1

[ HS Code ]:
2919900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

dichlorotriphenylphosphorane
Triphenylphosphine oxide
Piperazine
(2-Bromophenyl)(diphenyl)phosphine
bromotriphenylphosphonium bromide
Iodobenzene
Diphenylphosphine
Bromobenzene
phenyl-sodium

DownStream

4-cyano-N-(triphenyl-λ5-phosphanylidene)benzenesulfonamide
(11-methoxy-11-oxoundecyl)-triphenylphosphanium,iodide
(3-ETHOXYCARBONYL-2-OXOPROPLY)TRIPHENYLPHOSPHONIUM CHLORIDE
(4-chloro-3-methoxyphenyl)methyl-triphenylphosphanium,bromide
Triphenyl-[(3,4,5-trimethoxyphenyl)-methyl]-phosphonium chloride
(4-hydroxy-2-methylbut-2-enyl)-triphenylphosphanium,bromide
4-fluoro-N-(triphenyl-λ5-phosphanylidene)benzenesulfonamide
(3-METHOXYPROPYL)TRIPHENYLPHOSPHONIUM BROMIDE
3-oxopentan-2-yl(triphenyl)phosphanium,bromide
triphenyl-[[4-(2-phenylethenyl)phenyl]methyl]phosphanium,bromide

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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triphenylphosphine
PS-triphenylphosphine
triphenylphosphine-d15
triphenylphosphine-d15
Triphenylphosphine oxid
Pd(triphenylphosphine)3
[1-hexyl-5-(propan-2-yl)-1H-1,2,3-triazol-4-yl]methanamine
(5-cyclopropyl-1-hexyl-1H-1,2,3-triazol-4-yl)methanamine
4-(1-Aminocyclobutyl)-3-fluorophenol
1H-1,2,3-Triazole-4-methanamine, 1-hexyl-5-[(4-methylphenoxy)methyl]-
[1-hexyl-5-(methoxymethyl)-1H-1,2,3-triazol-4-yl]methanamine
[1-hexyl-5-(trifluoromethyl)-1H-1,2,3-triazol-4-yl]methanamine
(5-cyclobutyl-1-hexyl-1H-1,2,3-triazol-4-yl)methanamine
1-hexyl-5-methyl-1H-1,2,3-triazole-4-carboxamide
Methyl 2-(2-bromoacetyl)-5-methylbenzoate
4-(2-bromoacetyl)-1-methylpyridin-2(1H)-one

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