2H-naphth[1,8-cd]isothiazole 1,1-dioxide

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Names

[ CAS No. ]:
603-72-5

[ Name ]:
2H-naphth[1,8-cd]isothiazole 1,1-dioxide

[Synonym ]:
MFCD00009746
EINECS 210-055-4
1,8-Naphthalenesultam

Chemical & Physical Properties

[ Density]:
1.492g/cm3

[ Boiling Point ]:
442.2ºC at 760 mmHg

[ Melting Point ]:
173-175ºC(lit.)

[ Molecular Formula ]:
C10H7NO2S

[ Molecular Weight ]:
205.23300

[ Flash Point ]:
221.2ºC

[ Exact Mass ]:
205.02000

[ PSA ]:
54.55000

[ LogP ]:
3.17280

[ Index of Refraction ]:
1.727

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2934991000

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2934991000

[ Summary ]:
2934991000. sultones and sultams. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Synthesis and activity of 2-(sulfonamido)methyl-carbapenems: discovery of a novel, anti-MRSA 1,8-naphthosultam pharmacophore.

Bioorg. Med. Chem. Lett. 9(5) , 673-8, (1999)

A series of 1beta-methyl carbapenems substituted at the 2-position with lipophilic, acyclic and cyclic (sulfonamido)methyl groups was prepared and evaluated for activity against resistant gram-positiv...


More Articles

Related Compounds

  • 2-(3-chloropropyl)-2H-naphth[1,8-cd]isothiazole 1,1-dioxide
  • 2-(4-CHLOROBUTYL)-1LAMBDA6-NAPHTHO[1,8-CD]ISOTHIAZOLE-1,1(2H)-DIONE
  • 2H-naphth[1,8-cd]isothiazole-3,5-disulphonic acid 1,1-dioxide
  • 2-(2-bromoethyl)-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide
  • 2-acetyl-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide
  • N-(p-tolylsulfonyl)-1,8-naphthosultam