(-)-alpha-Narcotine

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Names

[ CAS No. ]:
6035-40-1

[ Name ]:
(-)-alpha-Narcotine

Chemical & Physical Properties

[ Density]:
1.332g/cm3

[ Boiling Point ]:
565.3ºC at 760 mmHg

[ Melting Point ]:
176ºC

[ Molecular Formula ]:
C₂₂H₂₃NO₇

[ Molecular Weight ]:
413.42100

[ Flash Point ]:
295.7ºC

[ Exact Mass ]:
413.14700

[ PSA ]:
75.69000

[ LogP ]:
2.81970

[ Index of Refraction ]:
1.602

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QN5600000

CHEMICAL NAME :: Narcotine, (+-)-

CAS REGISTRY NUMBER :: 6035-40-1

LAST UPDATED :: 199512

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C22-H23-N-O7

MOLECULAR WEIGHT :: 413.46

WISWESSER LINE NOTATION :: T C566 DO FO KN EH&&TJ HO1 K1 J- DT56 BVO DHJ HO1 IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 6,235,1950

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2784 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 15,640,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 491 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 15,640,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 83 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(1),206,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 73 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 7,372,1959

Related Compounds

7-O-DeMethyl α-Narcotine
(-)-alpha-Cedrene
ALPHA-MAN-[1->3][ALPHA-MAN-(1->6)]-ALPHA-MAN-[1->6][ALPHA-MAN-(1->3)]-MAN
alpha-amino-4-iodo-phenylacetic acid
alpha-Elemolic acid
alpha,2-dimethylcyclohexanemethanol
4-[4-(4,5-Dichlorothiophen-3-yl)pyrimidin-2-yl]morpholine
3-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)ethoxy]-4-methylbenzoic acid
7-(3,5-Dimethyl-1,2-oxazol-4-yl)-6-[(4-methoxyphenyl)methoxy]-N-(pyridin-2-ylmethyl)quinolin-4-amine
2,5-Dioxa-6-azaspiro[3.4]oct-6-ene-7-carboxylic acid
1,4-Dioxa-9-azaspiro[5.5]undecane-2-carboxylic acid
2-Chloro-1-spiro[2.3]hexan-5-ylethanone
3-Amino-3-(hydroxymethyl)spiro[3.3]heptan-1-ol
2-(9H-Fluoren-9-ylmethoxycarbonyl)-8-oxo-2,7-diazaspiro[3.5]nonane-5-carboxylic acid
5-(Azidomethyl)-1-bromo-2,3-dimethoxybenzene
1-(4-Methoxy-3-nitrophenyl)cyclopropane-1-carboxylic acid

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