3-Aminodihydro-2(3H)-thiophenone hydrochloride

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Names

[ CAS No. ]:
6038-19-3

[ Name ]:
3-Aminodihydro-2(3H)-thiophenone hydrochloride

[Synonym ]:
d,l-homocysteinthiolaktonchlorid
Hcy-thiolactone hydrochloride
Homocysteine thiolactone hydrochloride
DL-HOMOCYSTEINE THIOLACTONE HCL
3-Aminodihydro-2(3H)-thiophenone hydrochloride (1:1)
3-Aminodihydrothiophen-2(3H)-one hydrochloride (1:1)
HCTL hydrocloride salt
MFCD00012724
hctlhydrochloride
DL-HOMOCYSTEIN THIOLACTONE HCL
3-Aminodihydro-2(3H)-thiophenone hydrochloride
1,4-thiolactone hydrochloride
EINECS 227-923-3
2(3H)-Thiophenone, 3-aminodihydro-, hydrochloride (1:1)
DL-HCT
DL-Homocysteinethiol
D,L-homocysteine thiolactone hydrochloride

Chemical & Physical Properties

[ Density]:
0.862 g/cm3

[ Boiling Point ]:
253.8ºC at 760 mmHg

[ Melting Point ]:
202 °C (dec.)(lit.)

[ Molecular Formula ]:
C4H8ClNOS

[ Molecular Weight ]:
153.630

[ Flash Point ]:
107.3ºC

[ Exact Mass ]:
153.001511

[ PSA ]:
68.39000

[ LogP ]:
1.47950

[ Water Solubility ]:
740.5 g/L (20 C)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XN1928400
CHEMICAL NAME :
2(3H)-Thiophenone, dihydro-3-amino-, hydrochloride, (+-)-
CAS REGISTRY NUMBER :
6038-19-3
LAST UPDATED :
198903
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C4-H7-N-O-S.Cl-H
MOLECULAR WEIGHT :
153.64

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
770 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,72,1958

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
XN1928400

[ Packaging Group ]:
I; II

[ Hazard Class ]:
6.1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • D-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE
  • L-Homocysteine thiolactone hydrochloride

DownStream

  • D-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE
  • L-Homocysteine thiolactone hydrochloride
  • DL-Homocysteine
  • 2-CHLORO-N-(2-OXO-3-THIENYL)ACETAMIDE
  • Tert-Butyl (2-Oxotetrahydrothiophen-3-Yl)Carbamate
  • Citiolone
  • omonasteine

Articles

Water determination in active pharmaceutical ingredients using ionic liquid headspace gas chromatography and two different detection protocols.

J. Pharm. Biomed. Anal. 94 , 111-7, (2014)

A rapid, accurate, precise and versatile analytical method was developed for the detection and quantification of water in solid active pharmaceutical ingredients (APIs). The headspace gas chromatograp...

Comparison of the effect of homocysteine in the reduced form, its thiolactone and protein homocysteinylation on hemostatic properties of plasma.

Thromb. Res. 127(3) , 214-9, (2011)

Mechanisms involved in the relationship between hyperhomocysteinemia and hemostatic process are still unclear. In the literature there are few papers describing studies on the effects of homocysteine ...

Response of blood platelets to resveratrol during a model of hyperhomocysteinemia.

Platelets 22(4) , 277-83, (2011)

Resveratrol (3,4',5-trihydroxystilben), a phenolic antioxidant synthesized in grapes and other plants, and also present in wine, has been suggested to help prevent cardiovascular events. In this study...


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Related Compounds

  • (3S)-3-Aminodihydro-2(3H)-thiophenone hydrochloride (1:1)
  • 3-aminodihydro-2(3h)-furanone hydroiodide
  • 2(3H)-Thiophenone, 3-aminodihydro-4-(hydroxymethyl)- (9CI)
  • alpha-methylhomocysteine thiolactone
  • 3-Aminodihydrofuran-2(3H)-one hydrochloride
  • N-(3-Oxohexanoyl)homoserine lactone
  • 3-Fluoro-1-(oxirane-2-carbonyl)-3-phenylpiperidine
  • 1-{2-tert-butylimidazo[1,2-b]pyridazin-6-yl}-4-{2-methyl-5H,6H,7H-cyclopenta[d]pyrimidin-4-yl}piperazine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 2-(3,5-Dimethyl-1,2-oxazol-4-yl)-1-{5-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-octahydropyrrolo[3,4-c]pyrrol-2-yl}ethan-1-one