Amethopterin

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Names

[ CAS No. ]:
60388-53-6

[ Name ]:
Amethopterin

[Synonym ]:
amethopterin
4-amino-N10-methylpteroylglutamic acid
EINECS 262-213-7
MFCD00150845
4-amino-10-methylpteroyl-glutamic acid
D-methionine-R-sulfoximine
D-Methotrexat
2S,5S-Methionine sulfoximine

Chemical & Physical Properties

[ Density]:
1.536 g/cm3

[ Melting Point ]:
195ºC (dec.)(lit.)

[ Molecular Formula ]:
C20H22N8O5

[ Molecular Weight ]:
454.43900

[ Exact Mass ]:
454.17100

[ PSA ]:
210.54000

[ LogP ]:
1.82170

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA1224100
CHEMICAL NAME :
Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)b enzoyl)-, DL-
CAS REGISTRY NUMBER :
60388-53-6
LAST UPDATED :
199610
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H22-N8-O5
MOLECULAR WEIGHT :
454.50
WISWESSER LINE NOTATION :
T66 BN DN GN JNJ CZ EZ H1N1&R DVMYMQ2VQ -DL

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957- Volume(issue)/page/year: 29,43,1982

Safety Information

[ Hazard Codes ]:
T

[ Risk Phrases ]:
R46;R61

[ Safety Phrases ]:
S45-S53

[ RIDADR ]:
UN 1544 6.1/PG 2

Precursor & DownStream

Precursor

DownStream

  • 7-Hydroxymethotrexate

Related Compounds

  • Amethopterine
  • D-Amethopterin
  • D-Amethopterin
  • DL-Amethopterin
  • (+/-)AMETHOPTERIN
  • Dichloroamethopterin
  • N-[(1S,2S)-2-(Dimethylamino)cyclohexyl]-5-(1-naphthalenyl)-2-pyridinecarboxamide
  • 5,10,15,20-Tetrakis(3,5-dibromo-2,4,6-trimethylphenyl)-21H,23H-porphine
  • (3aR,8aR)-Tetrahydro-N,2,2-trimethyl-N,4,4,8,8-pentaphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-amine
  • N-benzyl-N-[2-(4-bromophenyl)sulfanyl-1,2-diphenylethyl]-10,16-diiodo-12,14-dioxa-13-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaen-13-amine
  • Dicyclohexyl[3-methoxy-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine
  • Dicyclohexyl[3',4',5'-trifluoro-3-(1-methylethoxy)-2',6'-bis(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine
  • (3R)-3-tert-butyl-2-ditert-butylphosphoryl-4-phenoxy-2H-1,3-benzoxaphosphole
  • (3aR,7aR)-1,3-Bis(2,4,6-trimethylbenzyl)octahydro-1H-benzo[d][1,3,2]diazaphosphole 2-oxide
  • (R)-N-[1-adamantyl-(2-ditert-butylphosphanylphenyl)methyl]-2-methylpropane-2-sulfinamide
  • Phospholane, 1,1'-(1,2-ethanediyl)bis[2,5-diphenyl-, 1,1'-dioxide, (2R,2'R,5R,5'R)-
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