Amethopterin

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Names

[ CAS No. ]:
60388-53-6

[ Name ]:
Amethopterin

[Synonym ]:
amethopterin
4-amino-N10-methylpteroylglutamic acid
EINECS 262-213-7
MFCD00150845
4-amino-10-methylpteroyl-glutamic acid
D-methionine-R-sulfoximine
D-Methotrexat
2S,5S-Methionine sulfoximine

Chemical & Physical Properties

[ Density]:
1.536 g/cm3

[ Melting Point ]:
195ºC (dec.)(lit.)

[ Molecular Formula ]:
C20H22N8O5

[ Molecular Weight ]:
454.43900

[ Exact Mass ]:
454.17100

[ PSA ]:
210.54000

[ LogP ]:
1.82170

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA1224100
CHEMICAL NAME :
Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)b enzoyl)-, DL-
CAS REGISTRY NUMBER :
60388-53-6
LAST UPDATED :
199610
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H22-N8-O5
MOLECULAR WEIGHT :
454.50
WISWESSER LINE NOTATION :
T66 BN DN GN JNJ CZ EZ H1N1&R DVMYMQ2VQ -DL

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957- Volume(issue)/page/year: 29,43,1982

Safety Information

[ Hazard Codes ]:
T

[ Risk Phrases ]:
R46;R61

[ Safety Phrases ]:
S45-S53

[ RIDADR ]:
UN 1544 6.1/PG 2

Precursor & DownStream

Precursor

DownStream

  • 7-Hydroxymethotrexate

Related Compounds

  • Amethopterine
  • D-Amethopterin
  • D-Amethopterin
  • DL-Amethopterin
  • (+/-)AMETHOPTERIN
  • Dichloroamethopterin
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • N-(2-Chloro-2-fluorocyclopropyl)-N-methylacetamide
  • (+/-)-tert-Butyl-1-methyl-8-oxo-7-azabicyclo[4.2.0]octane-7-carboxylate
  • 4-((1-((5-Chlorothiophen-2-yl)sulfonyl)pyrrolidin-3-yl)oxy)pyrimidine
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde