Bufuralol hydrochloride

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Names

[ CAS No. ]:
60398-91-6

[ Name ]:
Bufuralol hydrochloride

[Synonym ]:
1-(7-Ethyl-1-benzofuran-2-yl)-2-[(2-methyl-2-propanyl)amino]ethan ol hydrochloride (1:1)

Chemical & Physical Properties

[ Boiling Point ]:
393.2ºC at 760 mmHg

[ Melting Point ]:
143-146ºC

[ Molecular Formula ]:
C16H24ClNO2

[ Molecular Weight ]:
297.82000

[ Flash Point ]:
191.6ºC

[ Exact Mass ]:
297.15000

[ PSA ]:
45.40000

[ LogP ]:
4.60960

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-Bromobufuralol Hydrochloride
  • METHYL 3-ETHYL-4-HYDROXYBENZOATE
  • 5-bromo-7-ethyl-2-(1,2-epoxyethyl)benzofuran
  • 1-(5-bromo-7-ethyl-1-benzofuran-2-yl)-2-(tert-butylamino)ethanol
  • 5-Bromo-3-ethylsalicylaldehyde
  • 4-bromo-2-ethylphenyl allyl ether

DownStream

Articles

Binding of bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine to wild-type and F120A mutant cytochrome P450 2D6 studied by resonance Raman spectroscopy.

Biochem. Biophys. Res. Commun. 343(3) , 772-9, (2006)

Cytochrome P450 2D6 (CYP2D6) is one of the most important drug-metabolizing enzymes in humans. Resonance Raman data, reported for the first time for CYP2D6, show that the CYP2D6 heme is found to be in...

The ability of cytochrome P450 2D isoforms to synthesize dopamine in the brain: An in vitro study.

Eur. J. Pharmacol. 626(2-3) , 171-8, (2010)

The present study was aimed at determining which rat cytochrome P450 (CYP) isoforms are involved in the hydroxylation of tyramine to dopamine and at determining whether the reaction can take place in ...

Predictions of cytochrome P450-mediated drug-drug interactions using cryopreserved human hepatocytes: comparison of plasma and protein-free media incubation conditions.

Drug Metab. Dispos. 40(4) , 706-16, (2012)

Cryopreserved human hepatocytes suspended in human plasma (HHSHP) have previously provided accurate CYP3A drug-drug interaction (DDI) predictions from a single IC(50) that captures both reversible and...


More Articles

Related Compounds

  • d-Bufuralol Hydrochloride
  • l-Bufuralol Hydrochloride
  • (+/-)-bufuralol hydrochloride
  • Bufuralol-d9 (hydrochloride)
  • carnitine hydrochloride
  • Losoxantrone hydrochloride [USAN]
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • (9H-fluoren-9-yl)methyl (1R,5S,6R)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate
  • 4-Methyl-5,12-dithia-3-azatricyclo[7.3.0.0,2,6]dodeca-1,3,6,8,10-pentaen-8-yl 4-methylbenzene-1-sulfonate
  • tert-Butyl-DL-alanine